Ku70: A candidate tumor suppressor gene for murine T cell lymphoma

Gloria C. Li, Honghai Ouyang, Xiaoling Li, Hatsumi Nagasawa, John B. Little, David J. Chen, C. Clifton Ling, Zvi Fuks, Carlos Cordon-Cardo

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70-/- mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4+CD8+ tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMolecular cell
Volume2
Issue number1
DOIs
StatePublished - Jul 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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