L-asparaginase-provoked seizures as singular expression of central nervous toxicity

M. Y. Hamdan, E. P. Frenkel, R. Bick

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events. This syndrome generally occurs after a few weeks of therapy and may occur after L-asparaginase therapy is completed. Complications appear to result from depletion of plasma proteins involved in coagulation and fibrinolysis. Seizures are uncommon symptoms, and are always caused by cerebrovascular events. We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalClinical and Applied Thrombosis/Hemostasis
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2000

Keywords

  • CNS toxicity
  • L-Asparaginase
  • Lymphoma
  • Seizures

ASJC Scopus subject areas

  • Hematology

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