L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy

Christopher H. Gibbons, Steven A. Vernino, Horacio Kaufmann, Roy Freeman

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The authors report a 46-year-old woman with antibodies to the nicotinic acetylcholine receptor (NiAchR) of the autonomic ganglia. She presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading. Addition of L-threo-3,4-dihidroxyphenylserine (L-DOPS) substantially improved blood pressure and orthostatic tolerance. L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies.

Original languageEnglish (US)
Pages (from-to)1104-1106
Number of pages3
JournalNeurology
Volume65
Issue number7
DOIs
StatePublished - Oct 11 2005

ASJC Scopus subject areas

  • Clinical Neurology

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