Laboratory testing in pediatric cancer patients

Khushbu K Patel, William S. Phipps, Hung S. Luu, Dinesh Rakheja

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer is a leading cause of death in children; however, with modern treatments, most patients survive. Laboratory testing in the management of pediatric cancers is, in many ways, similar to that employed for adult populations. However, differences exist because of the differing types and proportions of cancers that occur in pediatrics compared to adults. Cancer biomarkers are routinely measured for cancer management and aid in screening, diagnosis, prognosis, and treatment monitoring. Very few tumor markers are organ- or tumor-specific and range from simple molecules and enzymes to heterogenous proteins with unique glycosylation patterns. This chapter will provide an overview of common pediatric malignancies and their clinical features with an emphasis on diagnostic features and biochemical markers that are most useful for diagnosis and monitoring childhood cancers.

Original languageEnglish (US)
Title of host publicationCancer Biomarkers
Subtitle of host publicationClinical Aspects and Laboratory Determination
PublisherElsevier
Pages31-65
Number of pages35
ISBN (Electronic)9780128243022
ISBN (Print)9780128243039
DOIs
StatePublished - Jan 1 2022

Keywords

  • brain tumors
  • Childhood malignancies
  • germ cell tumor
  • hepatoblastoma
  • leukemia
  • neuroblastoma
  • Wilms tumor

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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