Lack of effect of 24,25-dihydroxyvitamin D3 administration on parameters of calcium metabolism

J. A. Harvey, J. E. Zerwekh, K. Sakhaee, C. Y C Pak

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Abstract

Seven patients with disordered calcium metabolism and high normal or elevated serum 1,25-dihydoxyvitamin D [1,25-(OH)2D] were studied before and after the administration of 24,25-(OH)2D3 to determine its effects on calcium metabolism. Despite a significant increase in the mean serum 24,25-(OH)2D level [2.1 ± 0.6 (± SE) to 16.7 ± 6.2 nmol/L; P < 0.05] after a daily dose of 20 μg for 1 month, there were no consistent changes in serum calcium, immunoreactive PTH, or 1,25-(OH)2D concentrations. Intestinal calcium absorption and urinary calcium excretion rose slightly during 24,25-(OH)2D administration in the majority of the patients. In the three patients in whom it was measured, serum 24,25-trihydroxyvitamin D levels did not change (19 ± 5 vs. 20 ± 5 pmol/L). We conclude that exogenous 24,25-(OH)2D3 at this dose has no significant antagonistic action on 1,25-(OH)2D and may have weak agonistic action.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume69
Issue number2
StatePublished - 1989

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24,25-Dihydroxyvitamin D 3
Metabolism
Calcium
Serum
Intestinal Absorption

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lack of effect of 24,25-dihydroxyvitamin D3 administration on parameters of calcium metabolism. / Harvey, J. A.; Zerwekh, J. E.; Sakhaee, K.; Pak, C. Y C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 69, No. 2, 1989, p. 467-469.

Research output: Contribution to journalArticle

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