Abstract
Seven patients with disordered calcium metabolism and high normal or elevated serum 1,25-dihydoxyvitamin D [1,25-(OH)2D] were studied before and after the administration of 24,25-(OH)2D3 to determine its effects on calcium metabolism. Despite a significant increase in the mean serum 24,25-(OH)2D level [2.1 ± 0.6 (± SE) to 16.7 ± 6.2 nmol/L; P < 0.05] after a daily dose of 20 μg for 1 month, there were no consistent changes in serum calcium, immunoreactive PTH, or 1,25-(OH)2D concentrations. Intestinal calcium absorption and urinary calcium excretion rose slightly during 24,25-(OH)2D administration in the majority of the patients. In the three patients in whom it was measured, serum 24,25-trihydroxyvitamin D levels did not change (19 ± 5 vs. 20 ± 5 pmol/L). We conclude that exogenous 24,25-(OH)2D3 at this dose has no significant antagonistic action on 1,25-(OH)2D and may have weak agonistic action.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-469 |
| Number of pages | 3 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 69 |
| Issue number | 2 |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
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Lack of effect of 24,25-dihydroxyvitamin D3 administration on parameters of calcium metabolism. / Harvey, J. A.; Zerwekh, J. E.; Sakhaee, K.; Pak, C. Y C.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 69, No. 2, 1989, p. 467-469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of effect of 24,25-dihydroxyvitamin D3 administration on parameters of calcium metabolism
AU - Harvey, J. A.
AU - Zerwekh, J. E.
AU - Sakhaee, K.
AU - Pak, C. Y C
PY - 1989
Y1 - 1989
N2 - Seven patients with disordered calcium metabolism and high normal or elevated serum 1,25-dihydoxyvitamin D [1,25-(OH)2D] were studied before and after the administration of 24,25-(OH)2D3 to determine its effects on calcium metabolism. Despite a significant increase in the mean serum 24,25-(OH)2D level [2.1 ± 0.6 (± SE) to 16.7 ± 6.2 nmol/L; P < 0.05] after a daily dose of 20 μg for 1 month, there were no consistent changes in serum calcium, immunoreactive PTH, or 1,25-(OH)2D concentrations. Intestinal calcium absorption and urinary calcium excretion rose slightly during 24,25-(OH)2D administration in the majority of the patients. In the three patients in whom it was measured, serum 24,25-trihydroxyvitamin D levels did not change (19 ± 5 vs. 20 ± 5 pmol/L). We conclude that exogenous 24,25-(OH)2D3 at this dose has no significant antagonistic action on 1,25-(OH)2D and may have weak agonistic action.
AB - Seven patients with disordered calcium metabolism and high normal or elevated serum 1,25-dihydoxyvitamin D [1,25-(OH)2D] were studied before and after the administration of 24,25-(OH)2D3 to determine its effects on calcium metabolism. Despite a significant increase in the mean serum 24,25-(OH)2D level [2.1 ± 0.6 (± SE) to 16.7 ± 6.2 nmol/L; P < 0.05] after a daily dose of 20 μg for 1 month, there were no consistent changes in serum calcium, immunoreactive PTH, or 1,25-(OH)2D concentrations. Intestinal calcium absorption and urinary calcium excretion rose slightly during 24,25-(OH)2D administration in the majority of the patients. In the three patients in whom it was measured, serum 24,25-trihydroxyvitamin D levels did not change (19 ± 5 vs. 20 ± 5 pmol/L). We conclude that exogenous 24,25-(OH)2D3 at this dose has no significant antagonistic action on 1,25-(OH)2D and may have weak agonistic action.
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M3 - Article
C2 - 2787802
AN - SCOPUS:0024321440
VL - 69
SP - 467
EP - 469
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -