Lack of effect of lowering LDL cholesterol on cancer

Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration

J. De Lemos, E. Braunwald, M. Blazing, S. Murphy, J. R. Downs, A. Gotto, M. Clearfield, H. Holdaas, D. Gordon, B. Davis, M. Koren, B. Dahlof, James A de Lemos, P. Sever, R. H. Knopp, B. Fellström, H. Holdaas, A. Jardine, R. Schmieder, F. Zannad & 117 others U. Goldbourt, E. Kaplinsky, H. M. Colhoun, D. J. Betteridge, P. N. Durrington, G. A. Hitman, J. Fuller, A. Neil, C. Wanner, V. Krane, F. Sacks, L. Moyé, M. Pfeffer, C. M. Hawkins, E. Braunwald, J. Kjekshus, H. Wedel, J. Wikstrand, L. Tavazzi, A. Maggioni, R. Marchioli, G. Tognoni, M. G. Franzosi, A. Maggioni, R. Collins, J. Armitage, A. Keech, S. Parish, R. Peto, P. Sleight, T. R. Pedersen, P. M. Ridker, J. Simes, A. Keech, S. MacMahon, I. Marschner, A. Tonkin, J. Shaw, P. W. Serruys, H. Nakamura, G. Knatterud, C. Furberg, R. Byington, P. Macfarlane, S. Cobbe, I. Ford, M. Murphy, G. J. Blauw, C. Packard, J. Shepherd, J. Kjekshus, T. Pedersen, L. Wilhelmsen, E. Braunwald, C. Cannon, S. Murphy, R. Collins, J. Armitage, L. Bowman, S. Parish, R. Peto, P. Sleight, J. La Rosa, J. Shepherd, S. Cobbe, P. Macfarlane, I. Ford, M. Flather, J. Kastelein, C. Newman, C. Shear, J. Tobert, J. Varigos, H. White, S. Yusuf, A. Baxter, C. Baigent, E. H. Barnes, N. Bhala, L. Blackwell, G. Buck, R. Collins, J. Emberson, W. G. Herrington, L. E. Holland, P. M. Kearney, A. Keech, A. Kirby, D. A. Lewis, I. Marschner, C. Reith, J. Simes, M. Mellies, M. McGovern, J. Barclay, R. Belder, Y. Mitchell, T. Musliner, J. C. Ansquer, M. Llewellyn, M. Bortolini, B. Bryzinski, G. Olsson, J. Pears, D. De Micco, Jonathan R. Emberson, Patricia M. Kearney, Lisa Blackwell, Connie Newman, Christina Reith, Neeraj Bhala, Lisa Holland, Richard Peto, Anthony Keech, Rory Collins, John Simes, Colin Baigent

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (

Original languageEnglish (US)
Article numbere29849
JournalPLoS One
Volume7
Issue number1
DOIs
StatePublished - Jan 19 2012

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
low density lipoprotein cholesterol
meta-analysis
LDL Cholesterol
Meta-Analysis
Cholesterol
cholesterol
therapeutics
neoplasms
Neoplasms
Therapeutics
incidence
Mortality
Incidence
duration
blood vessels
Uncertainty
Blood Vessels
uncertainty
death

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lack of effect of lowering LDL cholesterol on cancer : Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration. / De Lemos, J.; Braunwald, E.; Blazing, M.; Murphy, S.; Downs, J. R.; Gotto, A.; Clearfield, M.; Holdaas, H.; Gordon, D.; Davis, B.; Koren, M.; Dahlof, B.; de Lemos, James A; Sever, P.; Knopp, R. H.; Fellström, B.; Holdaas, H.; Jardine, A.; Schmieder, R.; Zannad, F.; Goldbourt, U.; Kaplinsky, E.; Colhoun, H. M.; Betteridge, D. J.; Durrington, P. N.; Hitman, G. A.; Fuller, J.; Neil, A.; Wanner, C.; Krane, V.; Sacks, F.; Moyé, L.; Pfeffer, M.; Hawkins, C. M.; Braunwald, E.; Kjekshus, J.; Wedel, H.; Wikstrand, J.; Tavazzi, L.; Maggioni, A.; Marchioli, R.; Tognoni, G.; Franzosi, M. G.; Maggioni, A.; Collins, R.; Armitage, J.; Keech, A.; Parish, S.; Peto, R.; Sleight, P.; Pedersen, T. R.; Ridker, P. M.; Simes, J.; Keech, A.; MacMahon, S.; Marschner, I.; Tonkin, A.; Shaw, J.; Serruys, P. W.; Nakamura, H.; Knatterud, G.; Furberg, C.; Byington, R.; Macfarlane, P.; Cobbe, S.; Ford, I.; Murphy, M.; Blauw, G. J.; Packard, C.; Shepherd, J.; Kjekshus, J.; Pedersen, T.; Wilhelmsen, L.; Braunwald, E.; Cannon, C.; Murphy, S.; Collins, R.; Armitage, J.; Bowman, L.; Parish, S.; Peto, R.; Sleight, P.; La Rosa, J.; Shepherd, J.; Cobbe, S.; Macfarlane, P.; Ford, I.; Flather, M.; Kastelein, J.; Newman, C.; Shear, C.; Tobert, J.; Varigos, J.; White, H.; Yusuf, S.; Baxter, A.; Baigent, C.; Barnes, E. H.; Bhala, N.; Blackwell, L.; Buck, G.; Collins, R.; Emberson, J.; Herrington, W. G.; Holland, L. E.; Kearney, P. M.; Keech, A.; Kirby, A.; Lewis, D. A.; Marschner, I.; Reith, C.; Simes, J.; Mellies, M.; McGovern, M.; Barclay, J.; Belder, R.; Mitchell, Y.; Musliner, T.; Ansquer, J. C.; Llewellyn, M.; Bortolini, M.; Bryzinski, B.; Olsson, G.; Pears, J.; De Micco, D.; Emberson, Jonathan R.; Kearney, Patricia M.; Blackwell, Lisa; Newman, Connie; Reith, Christina; Bhala, Neeraj; Holland, Lisa; Peto, Richard; Keech, Anthony; Collins, Rory; Simes, John; Baigent, Colin.

In: PLoS One, Vol. 7, No. 1, e29849, 19.01.2012.

Research output: Contribution to journalArticle

De Lemos, J, Braunwald, E, Blazing, M, Murphy, S, Downs, JR, Gotto, A, Clearfield, M, Holdaas, H, Gordon, D, Davis, B, Koren, M, Dahlof, B, de Lemos, JA, Sever, P, Knopp, RH, Fellström, B, Holdaas, H, Jardine, A, Schmieder, R, Zannad, F, Goldbourt, U, Kaplinsky, E, Colhoun, HM, Betteridge, DJ, Durrington, PN, Hitman, GA, Fuller, J, Neil, A, Wanner, C, Krane, V, Sacks, F, Moyé, L, Pfeffer, M, Hawkins, CM, Braunwald, E, Kjekshus, J, Wedel, H, Wikstrand, J, Tavazzi, L, Maggioni, A, Marchioli, R, Tognoni, G, Franzosi, MG, Maggioni, A, Collins, R, Armitage, J, Keech, A, Parish, S, Peto, R, Sleight, P, Pedersen, TR, Ridker, PM, Simes, J, Keech, A, MacMahon, S, Marschner, I, Tonkin, A, Shaw, J, Serruys, PW, Nakamura, H, Knatterud, G, Furberg, C, Byington, R, Macfarlane, P, Cobbe, S, Ford, I, Murphy, M, Blauw, GJ, Packard, C, Shepherd, J, Kjekshus, J, Pedersen, T, Wilhelmsen, L, Braunwald, E, Cannon, C, Murphy, S, Collins, R, Armitage, J, Bowman, L, Parish, S, Peto, R, Sleight, P, La Rosa, J, Shepherd, J, Cobbe, S, Macfarlane, P, Ford, I, Flather, M, Kastelein, J, Newman, C, Shear, C, Tobert, J, Varigos, J, White, H, Yusuf, S, Baxter, A, Baigent, C, Barnes, EH, Bhala, N, Blackwell, L, Buck, G, Collins, R, Emberson, J, Herrington, WG, Holland, LE, Kearney, PM, Keech, A, Kirby, A, Lewis, DA, Marschner, I, Reith, C, Simes, J, Mellies, M, McGovern, M, Barclay, J, Belder, R, Mitchell, Y, Musliner, T, Ansquer, JC, Llewellyn, M, Bortolini, M, Bryzinski, B, Olsson, G, Pears, J, De Micco, D, Emberson, JR, Kearney, PM, Blackwell, L, Newman, C, Reith, C, Bhala, N, Holland, L, Peto, R, Keech, A, Collins, R, Simes, J & Baigent, C 2012, 'Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration', PLoS One, vol. 7, no. 1, e29849. https://doi.org/10.1371/journal.pone.0029849
De Lemos, J. ; Braunwald, E. ; Blazing, M. ; Murphy, S. ; Downs, J. R. ; Gotto, A. ; Clearfield, M. ; Holdaas, H. ; Gordon, D. ; Davis, B. ; Koren, M. ; Dahlof, B. ; de Lemos, James A ; Sever, P. ; Knopp, R. H. ; Fellström, B. ; Holdaas, H. ; Jardine, A. ; Schmieder, R. ; Zannad, F. ; Goldbourt, U. ; Kaplinsky, E. ; Colhoun, H. M. ; Betteridge, D. J. ; Durrington, P. N. ; Hitman, G. A. ; Fuller, J. ; Neil, A. ; Wanner, C. ; Krane, V. ; Sacks, F. ; Moyé, L. ; Pfeffer, M. ; Hawkins, C. M. ; Braunwald, E. ; Kjekshus, J. ; Wedel, H. ; Wikstrand, J. ; Tavazzi, L. ; Maggioni, A. ; Marchioli, R. ; Tognoni, G. ; Franzosi, M. G. ; Maggioni, A. ; Collins, R. ; Armitage, J. ; Keech, A. ; Parish, S. ; Peto, R. ; Sleight, P. ; Pedersen, T. R. ; Ridker, P. M. ; Simes, J. ; Keech, A. ; MacMahon, S. ; Marschner, I. ; Tonkin, A. ; Shaw, J. ; Serruys, P. W. ; Nakamura, H. ; Knatterud, G. ; Furberg, C. ; Byington, R. ; Macfarlane, P. ; Cobbe, S. ; Ford, I. ; Murphy, M. ; Blauw, G. J. ; Packard, C. ; Shepherd, J. ; Kjekshus, J. ; Pedersen, T. ; Wilhelmsen, L. ; Braunwald, E. ; Cannon, C. ; Murphy, S. ; Collins, R. ; Armitage, J. ; Bowman, L. ; Parish, S. ; Peto, R. ; Sleight, P. ; La Rosa, J. ; Shepherd, J. ; Cobbe, S. ; Macfarlane, P. ; Ford, I. ; Flather, M. ; Kastelein, J. ; Newman, C. ; Shear, C. ; Tobert, J. ; Varigos, J. ; White, H. ; Yusuf, S. ; Baxter, A. ; Baigent, C. ; Barnes, E. H. ; Bhala, N. ; Blackwell, L. ; Buck, G. ; Collins, R. ; Emberson, J. ; Herrington, W. G. ; Holland, L. E. ; Kearney, P. M. ; Keech, A. ; Kirby, A. ; Lewis, D. A. ; Marschner, I. ; Reith, C. ; Simes, J. ; Mellies, M. ; McGovern, M. ; Barclay, J. ; Belder, R. ; Mitchell, Y. ; Musliner, T. ; Ansquer, J. C. ; Llewellyn, M. ; Bortolini, M. ; Bryzinski, B. ; Olsson, G. ; Pears, J. ; De Micco, D. ; Emberson, Jonathan R. ; Kearney, Patricia M. ; Blackwell, Lisa ; Newman, Connie ; Reith, Christina ; Bhala, Neeraj ; Holland, Lisa ; Peto, Richard ; Keech, Anthony ; Collins, Rory ; Simes, John ; Baigent, Colin. / Lack of effect of lowering LDL cholesterol on cancer : Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration. In: PLoS One. 2012 ; Vol. 7, No. 1.
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title = "Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration",
abstract = "Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4{\%} per year [py]] versus 3738 [1.4{\%} py], RR 1.00 [95{\%} CI 0.96-1.05]; cancer mortality: 1365 [0.5{\%} py] versus 1358 [0.5{\%} py], RR 1.00 [95{\%} CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6{\%} py] vs 1472 [1.6{\%} py], RR 1.00 [95{\%} CI 0.93-1.07]; cancer mortality: 447 [0.5{\%} py] versus 481 [0.5{\%} py], RR 0.93 [95{\%} CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (",
author = "{De Lemos}, J. and E. Braunwald and M. Blazing and S. Murphy and Downs, {J. R.} and A. Gotto and M. Clearfield and H. Holdaas and D. Gordon and B. Davis and M. Koren and B. Dahlof and {de Lemos}, {James A} and P. Sever and Knopp, {R. H.} and B. Fellstr{\"o}m and H. Holdaas and A. Jardine and R. Schmieder and F. Zannad and U. Goldbourt and E. Kaplinsky and Colhoun, {H. M.} and Betteridge, {D. J.} and Durrington, {P. N.} and Hitman, {G. A.} and J. Fuller and A. Neil and C. Wanner and V. Krane and F. Sacks and L. Moy{\'e} and M. Pfeffer and Hawkins, {C. M.} and E. Braunwald and J. Kjekshus and H. Wedel and J. Wikstrand and L. Tavazzi and A. Maggioni and R. Marchioli and G. Tognoni and Franzosi, {M. G.} and A. Maggioni and R. Collins and J. Armitage and A. Keech and S. Parish and R. Peto and P. Sleight and Pedersen, {T. R.} and Ridker, {P. M.} and J. Simes and A. Keech and S. MacMahon and I. Marschner and A. Tonkin and J. Shaw and Serruys, {P. W.} and H. Nakamura and G. Knatterud and C. Furberg and R. Byington and P. Macfarlane and S. Cobbe and I. Ford and M. Murphy and Blauw, {G. J.} and C. Packard and J. Shepherd and J. Kjekshus and T. Pedersen and L. Wilhelmsen and E. Braunwald and C. Cannon and S. Murphy and R. Collins and J. Armitage and L. Bowman and S. Parish and R. Peto and P. Sleight and {La Rosa}, J. and J. Shepherd and S. Cobbe and P. Macfarlane and I. Ford and M. Flather and J. Kastelein and C. Newman and C. Shear and J. Tobert and J. Varigos and H. White and S. Yusuf and A. Baxter and C. Baigent and Barnes, {E. H.} and N. Bhala and L. Blackwell and G. Buck and R. Collins and J. Emberson and Herrington, {W. G.} and Holland, {L. E.} and Kearney, {P. M.} and A. Keech and A. Kirby and Lewis, {D. A.} and I. Marschner and C. Reith and J. Simes and M. Mellies and M. McGovern and J. Barclay and R. Belder and Y. Mitchell and T. Musliner and Ansquer, {J. C.} and M. Llewellyn and M. Bortolini and B. Bryzinski and G. Olsson and J. Pears and {De Micco}, D. and Emberson, {Jonathan R.} and Kearney, {Patricia M.} and Lisa Blackwell and Connie Newman and Christina Reith and Neeraj Bhala and Lisa Holland and Richard Peto and Anthony Keech and Rory Collins and John Simes and Colin Baigent",
year = "2012",
month = "1",
day = "19",
doi = "10.1371/journal.pone.0029849",
language = "English (US)",
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journal = "PLoS One",
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TY - JOUR

T1 - Lack of effect of lowering LDL cholesterol on cancer

T2 - Meta-analysis of individual data from 175,000 people in 27 randomised trials of Statin therapy: Cholesterol Treatment Trialists' (CTT) Collaboration

AU - De Lemos, J.

AU - Braunwald, E.

AU - Blazing, M.

AU - Murphy, S.

AU - Downs, J. R.

AU - Gotto, A.

AU - Clearfield, M.

AU - Holdaas, H.

AU - Gordon, D.

AU - Davis, B.

AU - Koren, M.

AU - Dahlof, B.

AU - de Lemos, James A

AU - Sever, P.

AU - Knopp, R. H.

AU - Fellström, B.

AU - Holdaas, H.

AU - Jardine, A.

AU - Schmieder, R.

AU - Zannad, F.

AU - Goldbourt, U.

AU - Kaplinsky, E.

AU - Colhoun, H. M.

AU - Betteridge, D. J.

AU - Durrington, P. N.

AU - Hitman, G. A.

AU - Fuller, J.

AU - Neil, A.

AU - Wanner, C.

AU - Krane, V.

AU - Sacks, F.

AU - Moyé, L.

AU - Pfeffer, M.

AU - Hawkins, C. M.

AU - Braunwald, E.

AU - Kjekshus, J.

AU - Wedel, H.

AU - Wikstrand, J.

AU - Tavazzi, L.

AU - Maggioni, A.

AU - Marchioli, R.

AU - Tognoni, G.

AU - Franzosi, M. G.

AU - Maggioni, A.

AU - Collins, R.

AU - Armitage, J.

AU - Keech, A.

AU - Parish, S.

AU - Peto, R.

AU - Sleight, P.

AU - Pedersen, T. R.

AU - Ridker, P. M.

AU - Simes, J.

AU - Keech, A.

AU - MacMahon, S.

AU - Marschner, I.

AU - Tonkin, A.

AU - Shaw, J.

AU - Serruys, P. W.

AU - Nakamura, H.

AU - Knatterud, G.

AU - Furberg, C.

AU - Byington, R.

AU - Macfarlane, P.

AU - Cobbe, S.

AU - Ford, I.

AU - Murphy, M.

AU - Blauw, G. J.

AU - Packard, C.

AU - Shepherd, J.

AU - Kjekshus, J.

AU - Pedersen, T.

AU - Wilhelmsen, L.

AU - Braunwald, E.

AU - Cannon, C.

AU - Murphy, S.

AU - Collins, R.

AU - Armitage, J.

AU - Bowman, L.

AU - Parish, S.

AU - Peto, R.

AU - Sleight, P.

AU - La Rosa, J.

AU - Shepherd, J.

AU - Cobbe, S.

AU - Macfarlane, P.

AU - Ford, I.

AU - Flather, M.

AU - Kastelein, J.

AU - Newman, C.

AU - Shear, C.

AU - Tobert, J.

AU - Varigos, J.

AU - White, H.

AU - Yusuf, S.

AU - Baxter, A.

AU - Baigent, C.

AU - Barnes, E. H.

AU - Bhala, N.

AU - Blackwell, L.

AU - Buck, G.

AU - Collins, R.

AU - Emberson, J.

AU - Herrington, W. G.

AU - Holland, L. E.

AU - Kearney, P. M.

AU - Keech, A.

AU - Kirby, A.

AU - Lewis, D. A.

AU - Marschner, I.

AU - Reith, C.

AU - Simes, J.

AU - Mellies, M.

AU - McGovern, M.

AU - Barclay, J.

AU - Belder, R.

AU - Mitchell, Y.

AU - Musliner, T.

AU - Ansquer, J. C.

AU - Llewellyn, M.

AU - Bortolini, M.

AU - Bryzinski, B.

AU - Olsson, G.

AU - Pears, J.

AU - De Micco, D.

AU - Emberson, Jonathan R.

AU - Kearney, Patricia M.

AU - Blackwell, Lisa

AU - Newman, Connie

AU - Reith, Christina

AU - Bhala, Neeraj

AU - Holland, Lisa

AU - Peto, Richard

AU - Keech, Anthony

AU - Collins, Rory

AU - Simes, John

AU - Baigent, Colin

PY - 2012/1/19

Y1 - 2012/1/19

N2 - Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (

AB - Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (

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U2 - 10.1371/journal.pone.0029849

DO - 10.1371/journal.pone.0029849

M3 - Article

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e29849

ER -