Lack of effect of prostaglandin inhibition on calcium excretion in normal volunteers

V. K. Rocco, K. Sakhaee, C. Y C Pak, D. C. Brater

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Recent data have shown that administration of indomethacin to patients with hypercalciuric nephrolithiasis decreased urinary calcium excretion, implying a possible pathogenic role for renal prostaglandins in hypercalciuria. To explore this hypothesis we administered indomethacin, ketoprofen and aspirin to normal volunteers for 6 days and assessed daily creatinine clearance and urinary excretion of sodium and calcium. In contrast to previous studies, subjects were maintained on a constant metabolic diet. These nonsteroidal anti-inflammatory drugs decreased urinary sodium excretion but had no effect on creatinine clearance or urinary calcium excretion. In summary, our data do not support an important physiologic role of renal prostaglandins in renal calcium excretion in normal subjects.

Original languageEnglish (US)
Pages (from-to)1093-1094
Number of pages2
JournalJournal of Urology
Volume133
Issue number6
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Urology

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