Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Chongshan Dai, Qinfeng Li, Herman I. May, Chao Li, Guangyu Zhang, Gaurav Sharma, A. Dean Sherry, Craig R. Malloy, Chalermchai Khemtong, Yuannyu Zhang, Yingfeng Deng, Thomas G. Gillette, Jian Xu, David T. Scadden, Zhao V. Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.

Original languageEnglish (US)
Article number108087
JournalCell Reports
Volume32
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • ERK
  • LDHA
  • NDRG3
  • cardiac hypertrophy
  • heart failure
  • lactate
  • pathological cardiac remodeling
  • pressure overload

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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