Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.
- cardiac hypertrophy
- heart failure
- pathological cardiac remodeling
- pressure overload
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)