Laforin is a cell membrane and endoplasmic reticulum-associated protein tyrosine phosphatase

Berge A. Minassian, Danielle M. Andrade, Leonarda Ianzano, Edwin J. Young, Elayne Chan, Cameron A. Ackerley, Stephen W. Scherer

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Lafora disease (LD) is the only progressive myoclonus epilepsy with polyglucosan bodies. Among conditions with polyglucosan bodies, LD is unique for the subcellular location of its polyglucosans in neuronal perikarya and dendrites and not in axons. Here we report that the protein encoded by the EPM2A gene, which is mutated in LD, localizes at the plasma membrane and the endoplasmic reticulum and that it is a functional protein tyrosine phosphatase. The significance of these findings in the epilepsy of LD and in the origin and characteristic subcellular location of Lafora bodies is discussed.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalAnnals of Neurology
Volume49
Issue number2
DOIs
StatePublished - Feb 27 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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