Lamina-associated polypeptide 1: Protein interactions and tissue-selective functions

Ji Yeon Shin, William T. Dauer, Howard J. Worman

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Mutations in genes encoding widely expressed nuclear envelope proteins often lead to diseases that manifest in specific tissues. Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that is expressed in most cells and tissues. Within the nuclear envelope, LAP1 interacts physically with lamins, torsinA and emerin, suggesting it may serve as a key node for transducing signals across the inner nuclear membrane. Indeed, recent in vivo studies in genetically modified mice strongly support functional links between LAP1 and both torsinA (in neurons) and emerin (in muscle). These studies suggest that tissue-selective diseases caused by mutations in genes encoding nuclear envelope proteins may result, at least in part, from the selective disruption of discrete nuclear envelope protein complexes.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalSeminars in Cell and Developmental Biology
Volume29
DOIs
StatePublished - May 2014

Keywords

  • Dystonia
  • Lamin
  • Muscular dystrophy
  • Nuclear envelope
  • Nuclear membrane

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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