Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization

Benjamin Chen, Suli Yuan, Pin Pin Hsu, John Y J Shyy, Shu Chien

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages7
Number of pages1
Volume1
ISBN (Print)0780356756
StatePublished - 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Phosphorylation
Endothelial cells
Cell growth
Laminar flow
Stabilization
JNK Mitogen-Activated Protein Kinases
Cell proliferation
Proteins

ASJC Scopus subject areas

  • Bioengineering

Cite this

Chen, B., Yuan, S., Hsu, P. P., Shyy, J. Y. J., & Chien, S. (1999). Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 7). Piscataway, NJ, United States: IEEE.

Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization. / Chen, Benjamin; Yuan, Suli; Hsu, Pin Pin; Shyy, John Y J; Chien, Shu.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 Piscataway, NJ, United States : IEEE, 1999. p. 7.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, B, Yuan, S, Hsu, PP, Shyy, JYJ & Chien, S 1999, Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, Piscataway, NJ, United States, pp. 7, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.
Chen B, Yuan S, Hsu PP, Shyy JYJ, Chien S. Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. Piscataway, NJ, United States: IEEE. 1999. p. 7
Chen, Benjamin ; Yuan, Suli ; Hsu, Pin Pin ; Shyy, John Y J ; Chien, Shu. / Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 Piscataway, NJ, United States : IEEE, 1999. pp. 7
@inproceedings{08a9818e42b24a92b00782c53f3ee57d,
title = "Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization",
abstract = "We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation.",
author = "Benjamin Chen and Suli Yuan and Hsu, {Pin Pin} and Shyy, {John Y J} and Shu Chien",
year = "1999",
language = "English (US)",
isbn = "0780356756",
volume = "1",
pages = "7",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",

}

TY - GEN

T1 - Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization

AU - Chen, Benjamin

AU - Yuan, Suli

AU - Hsu, Pin Pin

AU - Shyy, John Y J

AU - Chien, Shu

PY - 1999

Y1 - 1999

N2 - We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation.

AB - We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation.

UR - http://www.scopus.com/inward/record.url?scp=0033357873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033357873&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033357873

SN - 0780356756

VL - 1

SP - 7

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

PB - IEEE

CY - Piscataway, NJ, United States

ER -