Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

Heinz Grunze, Robert W. Greene, Hans Jürgen Möller, Thorsten Meyer, Jörg Walden

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I(D). This may be an effective mechanism to inhibit pathological excitation.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalBrain Research
Volume791
Issue number1-2
DOIs
StatePublished - Apr 27 1998

Keywords

  • Bipolar affective disorder
  • Epilepsy
  • Hippocampus
  • Lamotrigine
  • Potassium current

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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