Langerhans cells

Sentinels of skin associated lymphoid tissue

G. B. Toews, P. R. Bergstresser, J. W. Streilein

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Langerhans-cell-enriched epidermal cell preparations, when pulsed with antigen, can induce proliferative responses, in immune T cells, that are of the same magnitude as those induced by antigen-pulsed macrophages. Additionally, these cells bear surface receptors for Fc and C3b and display on their cell surfaces determinants encoded by genes of the I region of the major histocompatibility complex. Histological studies have implicated Langerhans cells in cell-mediated immune responses such as delayed contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB). Langerhans cells play an important role in the induction of contact sensitivity. When murine epidermis that is naturally or artificially depleted of Langerhans cells is painted with DNFB, no sensitization occurs. More importantly, animals whose initial exposure to DNFB occurs through skin deficient in Langerhans cells are unable subsequently to mount effective hypersensitivity responses to this agent. We therefore believe that Langerhans cells function as peripheral antigen-presenting cells and that in their absence the host responds to antigen challenge by becoming specifically unresponsive.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of Investigative Dermatology
Volume75
Issue number1
StatePublished - 1980

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Fluorobenzenes
Langerhans Cells
Lymphoid Tissue
Skin
Tissue
Antigens
T-cells
Macrophages
Contact Dermatitis
Cell Surface Receptors
Animals
Genes
Display devices
Delayed Hypersensitivity
Antigen-Presenting Cells
Major Histocompatibility Complex
Epidermis
cyhalothrin
Hypersensitivity
T-Lymphocytes

ASJC Scopus subject areas

  • Dermatology

Cite this

Toews, G. B., Bergstresser, P. R., & Streilein, J. W. (1980). Langerhans cells: Sentinels of skin associated lymphoid tissue. Journal of Investigative Dermatology, 75(1), 78-82.

Langerhans cells : Sentinels of skin associated lymphoid tissue. / Toews, G. B.; Bergstresser, P. R.; Streilein, J. W.

In: Journal of Investigative Dermatology, Vol. 75, No. 1, 1980, p. 78-82.

Research output: Contribution to journalArticle

Toews, GB, Bergstresser, PR & Streilein, JW 1980, 'Langerhans cells: Sentinels of skin associated lymphoid tissue', Journal of Investigative Dermatology, vol. 75, no. 1, pp. 78-82.
Toews, G. B. ; Bergstresser, P. R. ; Streilein, J. W. / Langerhans cells : Sentinels of skin associated lymphoid tissue. In: Journal of Investigative Dermatology. 1980 ; Vol. 75, No. 1. pp. 78-82.
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