TY - JOUR
T1 - Langerhans cells
T2 - Sentinels of skin associated lymphoid tissue
AU - Toews, G. B.
AU - Bergstresser, P. R.
AU - Streilein, J. W.
N1 - Funding Information:
Macher and Chase [5,6], using a chemical contact sensitivity model, have clearly demonstrated an inductive immunologic role for skin. They have shown that there is an initial phase during which the sensitizing hapten reacts directly with a constituent of skin. Although subsequent events in lymph nodes are important in processing the signal, interaction between the hapten and a skin constituent is required for expression of the response. Major histocompatability complex (MHC) products and macrophages play a central role in regulation of the immune response, especially as regards antigen presentation [7,8]. More This work was supported in part by US Public Health Service Grants CA-09082 and AI-10678. This work was performed while Dr. Toews was a postdoctoral research fellow of the Parker B. Francis Foundation. Reprint requests to: J. Wayne Streilein, M.D., Department of Cell Biology, Southwestern Medical School, Dallas, Texas 75235. Abbreviations: BAL T: bronchus-associated lymphoid tissue DNFB: 2,4-dinitro-1-fluorobenzene GALT: gut-associated lymphoid tissue MHC: major histocompatibility complex SALT: skin-associated lymphoid tissue UVL: ultraviolet light importantly, recent studies on contact sensitivity induction have also suggested a critical role for macrophages and MHC products [9-11]. The elegant transfer experiments of Vadas [12,13] have shown that T cells mediating the delayed hypersensitivity response to fowl gamma globulin recognize antigen in association with [-region determinants. In light of these experiments, it seems likely that the constituent responsible for the properties of skin observed by Macher and Chase might be macrophage-like cells that bear MHC products.
PY - 1980
Y1 - 1980
N2 - Langerhans-cell-enriched epidermal cell preparations, when pulsed with antigen, can induce proliferative responses, in immune T cells, that are of the same magnitude as those induced by antigen-pulsed macrophages. Additionally, these cells bear surface receptors for Fc and C3b and display on their cell surfaces determinants encoded by genes of the I region of the major histocompatibility complex. Histological studies have implicated Langerhans cells in cell-mediated immune responses such as delayed contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB). Langerhans cells play an important role in the induction of contact sensitivity. When murine epidermis that is naturally or artificially depleted of Langerhans cells is painted with DNFB, no sensitization occurs. More importantly, animals whose initial exposure to DNFB occurs through skin deficient in Langerhans cells are unable subsequently to mount effective hypersensitivity responses to this agent. We therefore believe that Langerhans cells function as peripheral antigen-presenting cells and that in their absence the host responds to antigen challenge by becoming specifically unresponsive.
AB - Langerhans-cell-enriched epidermal cell preparations, when pulsed with antigen, can induce proliferative responses, in immune T cells, that are of the same magnitude as those induced by antigen-pulsed macrophages. Additionally, these cells bear surface receptors for Fc and C3b and display on their cell surfaces determinants encoded by genes of the I region of the major histocompatibility complex. Histological studies have implicated Langerhans cells in cell-mediated immune responses such as delayed contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB). Langerhans cells play an important role in the induction of contact sensitivity. When murine epidermis that is naturally or artificially depleted of Langerhans cells is painted with DNFB, no sensitization occurs. More importantly, animals whose initial exposure to DNFB occurs through skin deficient in Langerhans cells are unable subsequently to mount effective hypersensitivity responses to this agent. We therefore believe that Langerhans cells function as peripheral antigen-presenting cells and that in their absence the host responds to antigen challenge by becoming specifically unresponsive.
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U2 - 10.1111/1523-1747.ep12521270
DO - 10.1111/1523-1747.ep12521270
M3 - Article
C2 - 7391612
AN - SCOPUS:0018869511
SN - 0022-202X
VL - 75
SP - 78
EP - 82
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -