Lanthanide complexes of adriamycin

R. E. Lenkinski, S. Sierke, M. R. Vist

Research output: Contribution to journalArticle

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Abstract

We investigated the interactions of the trivalent lanthanides with adriamycin in aqueous solution. In all the cases studied, the complexes were found to have a 1:1 stoichiometry. The complex formation process was found to be pH dependent with a pKa of about 8.2 which is the pKa of the amino group of the daunosamine. We also found that self-association of the adriamycin is important in aqueous solution. We analysed all our binding data to take this interaction into account. From an analysis of the temperature dependence of the binding constant we find that the enthalpy for the binding process is near zero while the entropy is about 25 cal K-1 mol-1. This result is consistent with the idea that the complex formation results in desolvation of the lanthanide ion.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalJournal of the Less-Common Metals
Volume94
Issue number2
DOIs
StatePublished - Oct 17 1983

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Lanthanoid Series Elements
Rare earth elements
Doxorubicin
Stoichiometry
Enthalpy
Entropy
Association reactions
Ions
Temperature
daunosamine

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lanthanide complexes of adriamycin. / Lenkinski, R. E.; Sierke, S.; Vist, M. R.

In: Journal of the Less-Common Metals, Vol. 94, No. 2, 17.10.1983, p. 359-365.

Research output: Contribution to journalArticle

Lenkinski, RE, Sierke, S & Vist, MR 1983, 'Lanthanide complexes of adriamycin', Journal of the Less-Common Metals, vol. 94, no. 2, pp. 359-365. https://doi.org/10.1016/0022-5088(83)90038-3
Lenkinski, R. E. ; Sierke, S. ; Vist, M. R. / Lanthanide complexes of adriamycin. In: Journal of the Less-Common Metals. 1983 ; Vol. 94, No. 2. pp. 359-365.
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