Lanthanide complexes of adriamycin

R. E. Lenkinski; S. Sierke; M. R. Vist

doi:10.1016/0022-5088(83)90038-3

Lanthanide complexes of adriamycin

R. E. Lenkinski, S. Sierke, M. R. Vist

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Abstract

We investigated the interactions of the trivalent lanthanides with adriamycin in aqueous solution. In all the cases studied, the complexes were found to have a 1:1 stoichiometry. The complex formation process was found to be pH dependent with a pK_a of about 8.2 which is the pK_a of the amino group of the daunosamine. We also found that self-association of the adriamycin is important in aqueous solution. We analysed all our binding data to take this interaction into account. From an analysis of the temperature dependence of the binding constant we find that the enthalpy for the binding process is near zero while the entropy is about 25 cal K^-1 mol^-1. This result is consistent with the idea that the complex formation results in desolvation of the lanthanide ion.

Original language	English (US)
Pages (from-to)	359-365
Number of pages	7
Journal	Journal of The Less-Common Metals
Volume	94
Issue number	2
DOIs	https://doi.org/10.1016/0022-5088(83)90038-3
State	Published - Oct 17 1983

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General Engineering

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10.1016/0022-5088(83)90038-3

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title = "Lanthanide complexes of adriamycin",

abstract = "We investigated the interactions of the trivalent lanthanides with adriamycin in aqueous solution. In all the cases studied, the complexes were found to have a 1:1 stoichiometry. The complex formation process was found to be pH dependent with a pKa of about 8.2 which is the pKa of the amino group of the daunosamine. We also found that self-association of the adriamycin is important in aqueous solution. We analysed all our binding data to take this interaction into account. From an analysis of the temperature dependence of the binding constant we find that the enthalpy for the binding process is near zero while the entropy is about 25 cal K-1 mol-1. This result is consistent with the idea that the complex formation results in desolvation of the lanthanide ion.",

author = "Lenkinski, {R. E.} and S. Sierke and Vist, {M. R.}",

note = "Funding Information: This work was supported by a grant from the Natural Science and Engineering Research Council of Canada (NSERC). The NMR experiments were performed at the Southwestern Ontario NMR Centre which was funded by a major installation grant from NSERC.",

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T1 - Lanthanide complexes of adriamycin

AU - Lenkinski, R. E.

AU - Sierke, S.

AU - Vist, M. R.

N1 - Funding Information: This work was supported by a grant from the Natural Science and Engineering Research Council of Canada (NSERC). The NMR experiments were performed at the Southwestern Ontario NMR Centre which was funded by a major installation grant from NSERC.

PY - 1983/10/17

Y1 - 1983/10/17

N2 - We investigated the interactions of the trivalent lanthanides with adriamycin in aqueous solution. In all the cases studied, the complexes were found to have a 1:1 stoichiometry. The complex formation process was found to be pH dependent with a pKa of about 8.2 which is the pKa of the amino group of the daunosamine. We also found that self-association of the adriamycin is important in aqueous solution. We analysed all our binding data to take this interaction into account. From an analysis of the temperature dependence of the binding constant we find that the enthalpy for the binding process is near zero while the entropy is about 25 cal K-1 mol-1. This result is consistent with the idea that the complex formation results in desolvation of the lanthanide ion.

AB - We investigated the interactions of the trivalent lanthanides with adriamycin in aqueous solution. In all the cases studied, the complexes were found to have a 1:1 stoichiometry. The complex formation process was found to be pH dependent with a pKa of about 8.2 which is the pKa of the amino group of the daunosamine. We also found that self-association of the adriamycin is important in aqueous solution. We analysed all our binding data to take this interaction into account. From an analysis of the temperature dependence of the binding constant we find that the enthalpy for the binding process is near zero while the entropy is about 25 cal K-1 mol-1. This result is consistent with the idea that the complex formation results in desolvation of the lanthanide ion.

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Lanthanide complexes of adriamycin

Abstract

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