Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

Zohreh Hashami, Andre F. Martins, Alexander M. Funk, Veronica Clavijo Jordan, Stéphane Petoud, Svetlana V. Eliseeva, Zoltan Kovacs

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand 1). Ln3+ complexes of 1 have one inner-sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd1 and Yb1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln3+ ions. Therefore, this new ligand is a promising platform for the design of Ln3+-based dual MR/optical imaging probes.

Original languageEnglish (US)
JournalEuropean Journal of Inorganic Chemistry
DOIs
StateAccepted/In press - 2017

Fingerprint

Lanthanoid Series Elements
Ligands
Imaging techniques
Water
Magnetic resonance imaging
Ions
Atoms
Molecules
tropone

Keywords

  • Fluorescent probes
  • Imaging agents
  • Lanthanides
  • Luminescence
  • Tropones

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Lanthanide DO3A-Tropone Complexes : Efficient Dual MR/NIR Imaging Probes in Aqueous Medium. / Hashami, Zohreh; Martins, Andre F.; Funk, Alexander M.; Jordan, Veronica Clavijo; Petoud, Stéphane; Eliseeva, Svetlana V.; Kovacs, Zoltan.

In: European Journal of Inorganic Chemistry, 2017.

Research output: Contribution to journalArticle

Hashami, Zohreh ; Martins, Andre F. ; Funk, Alexander M. ; Jordan, Veronica Clavijo ; Petoud, Stéphane ; Eliseeva, Svetlana V. ; Kovacs, Zoltan. / Lanthanide DO3A-Tropone Complexes : Efficient Dual MR/NIR Imaging Probes in Aqueous Medium. In: European Journal of Inorganic Chemistry. 2017.
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