TY - JOUR
T1 - Lanthanide DO3A-Tropone Complexes
T2 - Efficient Dual MR/NIR Imaging Probes in Aqueous Medium
AU - Hashami, Zohreh
AU - Martins, Andre F.
AU - Funk, Alexander M.
AU - Jordan, Veronica Clavijo
AU - Petoud, Stéphane
AU - Eliseeva, Svetlana V.
AU - Kovacs, Zoltan
N1 - Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/11/24
Y1 - 2017/11/24
N2 - In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand 1). Ln3+ complexes of 1 have one inner-sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd1 and Yb1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln3+ ions. Therefore, this new ligand is a promising platform for the design of Ln3+-based dual MR/optical imaging probes.
AB - In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand 1). Ln3+ complexes of 1 have one inner-sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd1 and Yb1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln3+ ions. Therefore, this new ligand is a promising platform for the design of Ln3+-based dual MR/optical imaging probes.
KW - Fluorescent probes
KW - Imaging agents
KW - Lanthanides
KW - Luminescence
KW - Tropones
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U2 - 10.1002/ejic.201701003
DO - 10.1002/ejic.201701003
M3 - Article
C2 - 30288139
AN - SCOPUS:85029449462
SN - 1434-1948
VL - 2017
SP - 4965
EP - 4968
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
IS - 43
ER -