Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents

Federico A. Rojas-Quijano; Eniko Tircsóné Benyó; Gyula Tircsó; Ferenc K. Kálmán; Zsolt Baranyai; Silvio Aime; Dean A. Sherry; Zoltán Kovács

doi:10.1002/chem.200901095

Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents

Federico A. Rojas-Quijano, Eniko Tircsóné Benyó, Gyula Tircsó, Ferenc K. Kálmán, Zsolt Baranyai, Silvio Aime, Dean A. Sherry, Zoltán Kovács

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb ^III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding Gd^III complexes display unusually high T₁ relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.

Original language	English (US)
Pages (from-to)	13188-13200
Number of pages	13
Journal	Chemistry - A European Journal
Volume	15
Issue number	47
DOIs	https://doi.org/10.1002/chem.200901095
State	Published - Dec 7 2009

Keywords

Imaging agents
Lanthanides
PARACEST
Water chemistry

ASJC Scopus subject areas

General Chemistry
Catalysis
Organic Chemistry

Access to Document

10.1002/chem.200901095

Cite this

@article{ea9f65eb6d4c4e0ca55adeae3a572295,

title = "Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents",

abstract = "Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding GdIII complexes display unusually high T1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.",

keywords = "Imaging agents, Lanthanides, PARACEST, Water chemistry",

author = "Rojas-Quijano, {Federico A.} and Beny{\'o}, {Eniko Tircs{\'o}n{\'e}} and Gyula Tircs{\'o} and K{\'a}lm{\'a}n, {Ferenc K.} and Zsolt Baranyai and Silvio Aime and Sherry, {Dean A.} and Zolt{\'a}n Kov{\'a}cs",

year = "2009",

month = dec,

day = "7",

doi = "10.1002/chem.200901095",

language = "English (US)",

volume = "15",

pages = "13188--13200",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "47",

}

TY - JOUR

T1 - Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents

AU - Rojas-Quijano, Federico A.

AU - Benyó, Eniko Tircsóné

AU - Tircsó, Gyula

AU - Kálmán, Ferenc K.

AU - Baranyai, Zsolt

AU - Aime, Silvio

AU - Sherry, Dean A.

AU - Kovács, Zoltán

PY - 2009/12/7

Y1 - 2009/12/7

N2 - Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding GdIII complexes display unusually high T1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.

AB - Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding GdIII complexes display unusually high T1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.

KW - Imaging agents

KW - Lanthanides

KW - PARACEST

KW - Water chemistry

UR - http://www.scopus.com/inward/record.url?scp=73349102775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349102775&partnerID=8YFLogxK

U2 - 10.1002/chem.200901095

DO - 10.1002/chem.200901095

M3 - Article

C2 - 19882595

AN - SCOPUS:73349102775

SN - 0947-6539

VL - 15

SP - 13188

EP - 13200

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 47

ER -

Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this