Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents

Federico A. Rojas-Quijano, Eniko Tircsóné Benyó, Gyula Tircsó, Ferenc K. Kálmán, Zsolt Baranyai, Silvio Aime, Dean A. Sherry, Zoltán Kovács

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding GdIII complexes display unusually high T1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.

Original languageEnglish (US)
Pages (from-to)13188-13200
Number of pages13
JournalChemistry - A European Journal
Volume15
Issue number47
DOIs
StatePublished - Dec 7 2009

Keywords

  • Imaging agents
  • Lanthanides
  • PARACEST
  • Water chemistry

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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