Abstract
We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The plasma level of ORG 10172 was monitored by the degree of inhibition of coagulation factor Xa. In general, the drug was well tolerated and few hemorrhagic complications occurred. Two patients with large cardioembolic hemispheric strokes had intracranial hemorrhagic complications. Most patients improved during treatment. By 3 months after the stroke, 37 patients (65%) had a favorable outcome (minimal or no residual disability). This study suggests that high-dose intravenous infusions of ORG 10172 can be safely given to patients with acute ischemic stroke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1289-1292 |
| Number of pages | 4 |
| Journal | Stroke |
| Volume | 21 |
| Issue number | 9 |
| State | Published - Sep 1990 |
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Keywords
- Anticoagulants
- Cerebral ischemia
- Early treatment
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Neuroscience(all)
Cite this
Large-dose infusions of heparinoid ORG 10172 in ischemic stroke. / Massey, E. W.; Biller, J.; Davis, J. N.; Adams, H. P.; Marler, J. R.; Goldstein, L. B.; Alberts, M.; Bruno, A.
In: Stroke, Vol. 21, No. 9, 09.1990, p. 1289-1292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Large-dose infusions of heparinoid ORG 10172 in ischemic stroke
AU - Massey, E. W.
AU - Biller, J.
AU - Davis, J. N.
AU - Adams, H. P.
AU - Marler, J. R.
AU - Goldstein, L. B.
AU - Alberts, M.
AU - Bruno, A.
PY - 1990/9
Y1 - 1990/9
N2 - We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The plasma level of ORG 10172 was monitored by the degree of inhibition of coagulation factor Xa. In general, the drug was well tolerated and few hemorrhagic complications occurred. Two patients with large cardioembolic hemispheric strokes had intracranial hemorrhagic complications. Most patients improved during treatment. By 3 months after the stroke, 37 patients (65%) had a favorable outcome (minimal or no residual disability). This study suggests that high-dose intravenous infusions of ORG 10172 can be safely given to patients with acute ischemic stroke.
AB - We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The plasma level of ORG 10172 was monitored by the degree of inhibition of coagulation factor Xa. In general, the drug was well tolerated and few hemorrhagic complications occurred. Two patients with large cardioembolic hemispheric strokes had intracranial hemorrhagic complications. Most patients improved during treatment. By 3 months after the stroke, 37 patients (65%) had a favorable outcome (minimal or no residual disability). This study suggests that high-dose intravenous infusions of ORG 10172 can be safely given to patients with acute ischemic stroke.
KW - Anticoagulants
KW - Cerebral ischemia
KW - Early treatment
UR - http://www.scopus.com/inward/record.url?scp=0025183006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025183006&partnerID=8YFLogxK
M3 - Article
C2 - 2396265
AN - SCOPUS:0025183006
VL - 21
SP - 1289
EP - 1292
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 9
ER -