TY - GEN
T1 - Laser speckle imaging reveals multiple aspects of cerebral vascular responses to whole body mild hypothermia in rats
AU - Li, Nan
AU - Thakor, Nitish V.
AU - Jia, Xiaofeng
PY - 2011
Y1 - 2011
N2 - In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. Experiments were carried out in rats under anesthesia. Laser speckle images were acquired at different temperature points, normothermia (37 Q and mild therapeutic hypothermia (34 Q. We extracted multiple hemodynamic responses simultaneously from the images, including blood flow, vessel size and deoxy-hemoglobin saturation. A wide-field view of the cerebral vascular response distribution was studied, which showed an inhomogeneous response map across the region of interest. A comparison between responses in arterioles and venules was carried out (blood flow decreased by 58 9 % vs. 27 8 %). The global decrease of blood flow, dilatation in arterioles and decrease of deoxy-hemoglobin saturation in veins at mild hypothermia suggests a beneficial role of circulatory and oxygenation changes in therapeutic hypothermia. The results reported provide a circulatory explanation for the hypothermia therapeutic effects and mechanism.
AB - In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. Experiments were carried out in rats under anesthesia. Laser speckle images were acquired at different temperature points, normothermia (37 Q and mild therapeutic hypothermia (34 Q. We extracted multiple hemodynamic responses simultaneously from the images, including blood flow, vessel size and deoxy-hemoglobin saturation. A wide-field view of the cerebral vascular response distribution was studied, which showed an inhomogeneous response map across the region of interest. A comparison between responses in arterioles and venules was carried out (blood flow decreased by 58 9 % vs. 27 8 %). The global decrease of blood flow, dilatation in arterioles and decrease of deoxy-hemoglobin saturation in veins at mild hypothermia suggests a beneficial role of circulatory and oxygenation changes in therapeutic hypothermia. The results reported provide a circulatory explanation for the hypothermia therapeutic effects and mechanism.
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U2 - 10.1109/IEMBS.2011.6090378
DO - 10.1109/IEMBS.2011.6090378
M3 - Conference contribution
C2 - 22254739
AN - SCOPUS:84862242931
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2049
EP - 2052
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -