Late outcomes after carotid artery stenting versus carotid endarterectomy: Insights from a propensity-matched analysis of the reduction of atherothrombosis for continued health (REACH) registry

Sripal Bangalore, Deepak L. Bhatt, Joachim Röther, Mark J. Alberts, Julie Thornton, Kathy Wolski, Shinya Goto, Alan T. Hirsch, Sidney C. Smith, Franz T. Aichner, Raffi Topakian, Christopher P. Cannon, P. Gabriel Steg

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background-: In patients with carotid artery disease, carotid endarterectomy (CEA) and carotid stenting (CAS) are treatment options. Controversy exists as to the relative efficacy of the 2 techniques in preventing late events. Methods and Results-: The Reduction of Atherothrombosis for Continued Health (REACH) Registry recruited >68 000 outpatients ≥45 years of age with established atherothrombotic disease or ≥3 risk factors for atherothrombosis. Patients with CAS or CEA were chosen and followed up prospectively for the occurrence of cardiovascular events. Propensity score matching was performed to assemble a cohort of patients in whom all baseline covariates would be well balanced. Primary outcome was defined as death or stroke at the 2-year follow-up. Secondary outcome was stroke or transient ischemic attack. Tertiary outcome was a composite of death, myocardial infarction, or stroke and the individual outcomes. Of the 68 236 patients with atherothrombosis, 3412 patients (5%) had a history of carotid artery revascularization (70% asymptomatic carotid stenosis), 1025 (30%) with CAS and 2387 (70%) with CEA. Propensity score analyses matched 836 CAS patients with 836 CEA patients. At the end of 2 years of follow-up, in the propensity score-matched cohort, CAS was associated with a risk similar to CEA for the primary (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.57 to 1.26), secondary (HR, 1.20; 95% CI, 0.73 to 1.96), and tertiary (HR, 0.72; 95% CI, 0.51 to 1.01) composite outcome, death (HR, 0.63; 95% CI, 0.40 to 1.00), and stroke (HR, 1.48; 95% CI, 0.79 to 2.80). CONCLUSION-: In a real-world cohort of patients with a history of carotid artery revascularization, CAS was comparable to CEA for late outcomes.

Original languageEnglish (US)
Pages (from-to)1091-1100
Number of pages10
JournalCirculation
Volume122
Issue number11
DOIs
StatePublished - Sep 14 2010

Fingerprint

Carotid Endarterectomy
Carotid Arteries
Registries
Health
Propensity Score
Confidence Intervals
Stroke
Carotid Artery Diseases
Carotid Stenosis
Transient Ischemic Attack
Outpatients
Myocardial Infarction

Keywords

  • carotid arteries
  • endarterectomy
  • prognosis
  • stents

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Late outcomes after carotid artery stenting versus carotid endarterectomy : Insights from a propensity-matched analysis of the reduction of atherothrombosis for continued health (REACH) registry. / Bangalore, Sripal; Bhatt, Deepak L.; Röther, Joachim; Alberts, Mark J.; Thornton, Julie; Wolski, Kathy; Goto, Shinya; Hirsch, Alan T.; Smith, Sidney C.; Aichner, Franz T.; Topakian, Raffi; Cannon, Christopher P.; Steg, P. Gabriel.

In: Circulation, Vol. 122, No. 11, 14.09.2010, p. 1091-1100.

Research output: Contribution to journalArticle

Bangalore, S, Bhatt, DL, Röther, J, Alberts, MJ, Thornton, J, Wolski, K, Goto, S, Hirsch, AT, Smith, SC, Aichner, FT, Topakian, R, Cannon, CP & Steg, PG 2010, 'Late outcomes after carotid artery stenting versus carotid endarterectomy: Insights from a propensity-matched analysis of the reduction of atherothrombosis for continued health (REACH) registry', Circulation, vol. 122, no. 11, pp. 1091-1100. https://doi.org/10.1161/CIRCULATIONAHA.109.933341
Bangalore, Sripal ; Bhatt, Deepak L. ; Röther, Joachim ; Alberts, Mark J. ; Thornton, Julie ; Wolski, Kathy ; Goto, Shinya ; Hirsch, Alan T. ; Smith, Sidney C. ; Aichner, Franz T. ; Topakian, Raffi ; Cannon, Christopher P. ; Steg, P. Gabriel. / Late outcomes after carotid artery stenting versus carotid endarterectomy : Insights from a propensity-matched analysis of the reduction of atherothrombosis for continued health (REACH) registry. In: Circulation. 2010 ; Vol. 122, No. 11. pp. 1091-1100.
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abstract = "Background-: In patients with carotid artery disease, carotid endarterectomy (CEA) and carotid stenting (CAS) are treatment options. Controversy exists as to the relative efficacy of the 2 techniques in preventing late events. Methods and Results-: The Reduction of Atherothrombosis for Continued Health (REACH) Registry recruited >68 000 outpatients ≥45 years of age with established atherothrombotic disease or ≥3 risk factors for atherothrombosis. Patients with CAS or CEA were chosen and followed up prospectively for the occurrence of cardiovascular events. Propensity score matching was performed to assemble a cohort of patients in whom all baseline covariates would be well balanced. Primary outcome was defined as death or stroke at the 2-year follow-up. Secondary outcome was stroke or transient ischemic attack. Tertiary outcome was a composite of death, myocardial infarction, or stroke and the individual outcomes. Of the 68 236 patients with atherothrombosis, 3412 patients (5{\%}) had a history of carotid artery revascularization (70{\%} asymptomatic carotid stenosis), 1025 (30{\%}) with CAS and 2387 (70{\%}) with CEA. Propensity score analyses matched 836 CAS patients with 836 CEA patients. At the end of 2 years of follow-up, in the propensity score-matched cohort, CAS was associated with a risk similar to CEA for the primary (hazard ratio [HR], 0.85; 95{\%} confidence interval [CI], 0.57 to 1.26), secondary (HR, 1.20; 95{\%} CI, 0.73 to 1.96), and tertiary (HR, 0.72; 95{\%} CI, 0.51 to 1.01) composite outcome, death (HR, 0.63; 95{\%} CI, 0.40 to 1.00), and stroke (HR, 1.48; 95{\%} CI, 0.79 to 2.80). CONCLUSION-: In a real-world cohort of patients with a history of carotid artery revascularization, CAS was comparable to CEA for late outcomes.",
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T2 - Insights from a propensity-matched analysis of the reduction of atherothrombosis for continued health (REACH) registry

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AU - Bhatt, Deepak L.

AU - Röther, Joachim

AU - Alberts, Mark J.

AU - Thornton, Julie

AU - Wolski, Kathy

AU - Goto, Shinya

AU - Hirsch, Alan T.

AU - Smith, Sidney C.

AU - Aichner, Franz T.

AU - Topakian, Raffi

AU - Cannon, Christopher P.

AU - Steg, P. Gabriel

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N2 - Background-: In patients with carotid artery disease, carotid endarterectomy (CEA) and carotid stenting (CAS) are treatment options. Controversy exists as to the relative efficacy of the 2 techniques in preventing late events. Methods and Results-: The Reduction of Atherothrombosis for Continued Health (REACH) Registry recruited >68 000 outpatients ≥45 years of age with established atherothrombotic disease or ≥3 risk factors for atherothrombosis. Patients with CAS or CEA were chosen and followed up prospectively for the occurrence of cardiovascular events. Propensity score matching was performed to assemble a cohort of patients in whom all baseline covariates would be well balanced. Primary outcome was defined as death or stroke at the 2-year follow-up. Secondary outcome was stroke or transient ischemic attack. Tertiary outcome was a composite of death, myocardial infarction, or stroke and the individual outcomes. Of the 68 236 patients with atherothrombosis, 3412 patients (5%) had a history of carotid artery revascularization (70% asymptomatic carotid stenosis), 1025 (30%) with CAS and 2387 (70%) with CEA. Propensity score analyses matched 836 CAS patients with 836 CEA patients. At the end of 2 years of follow-up, in the propensity score-matched cohort, CAS was associated with a risk similar to CEA for the primary (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.57 to 1.26), secondary (HR, 1.20; 95% CI, 0.73 to 1.96), and tertiary (HR, 0.72; 95% CI, 0.51 to 1.01) composite outcome, death (HR, 0.63; 95% CI, 0.40 to 1.00), and stroke (HR, 1.48; 95% CI, 0.79 to 2.80). CONCLUSION-: In a real-world cohort of patients with a history of carotid artery revascularization, CAS was comparable to CEA for late outcomes.

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