TY - JOUR
T1 - Late outcomes of adult survivors of childhood non-Hodgkin lymphoma
T2 - A report from the St. Jude Lifetime Cohort Study
AU - Ehrhardt, Matthew J.
AU - Sandlund, John T.
AU - Zhang, Nan
AU - Liu, Wei
AU - Ness, Kirsten K.
AU - Bhakta, Nickhill
AU - Chemaitilly, Wassim
AU - Krull, Kevin R.
AU - Brinkman, Tara M.
AU - Crom, Deborah B.
AU - Kun, Larry
AU - Kaste, Sue C.
AU - Armstrong, Gregory T.
AU - Green, Daniel M.
AU - Srivastava, Kumar
AU - Robison, Leslie L.
AU - Hudson, Melissa M.
AU - Mulrooney, Daniel A.
N1 - Funding Information:
We appreciate the research, clinical, and administrative staff who support SJLIFE and the survivors and their families from whom it is our privilege to learn. SFLIFE is supported by the Cancer Center Support (CORE) Grant (CA21765) to SJCRH, U01 CA195547 1 (PI: Dr. Melissa M. Hudson), and the American Lebanese Syrian Associated Charities (ALSAC), Memphis, TN. The authors thank Sheila Shope and Robyn Partin for assistance with data management, and Taryn Donley for technical support with the manuscript preparation. The authors declare that there is no conflict of interest. Study concepts: M.J.E., J.T.S., M.M.H., L.L.R., and D.A.M.; Study design: M.J.E., J.T.S., M.M.H., L.L.R., and D.A.M.; Data acquisition: M.J.E., D.B.C., N.Z., N.B., K.S., T.M.B., K.R.K., K.K.N., W.C., L.L.R., and D.A.M.; Quality control of data and algorithms: M.M.H., L.L.R., K.K.N., and K.S.; Data analysis and interpretation: all authors; Statistical analysis: N.Z., K.S., M.J.E., D.A.M., and W.L.; manuscript preparation, editing, review were performed by all authors.
Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2017/6
Y1 - 2017/6
N2 - Background: Survivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors. Method: Chronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data. Multivariable regression was used to investigate associations between sociodemographic characteristics, therapeutic exposures, and outcomes. Results: Survivors were a median age of 10 years (range 1–19) at diagnosis and 34 years (range 20–58) at evaluation. Eighty-eight (44%) received radiation, 46 (23%) cranial radiation, and 69 (35%) high-dose methotrexate. Most prevalent CTCAE Grades 3–4 (severe life-threatening) conditions were obesity (35%), hypertension (9%), and impairment of executive function (13%), attention (9%), and memory (4%). Many had impaired strength (48%), flexibility (39%), muscular endurance (36%), and mobility (36%). Demographic and treatment-related factors were associated with the development of individual chronic diseases and functional deficits. Conclusions: Clinical evaluation identified a high prevalence of chronic health conditions, neurocognitive deficits, and performance limitations in childhood NHL survivors.
AB - Background: Survivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors. Method: Chronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data. Multivariable regression was used to investigate associations between sociodemographic characteristics, therapeutic exposures, and outcomes. Results: Survivors were a median age of 10 years (range 1–19) at diagnosis and 34 years (range 20–58) at evaluation. Eighty-eight (44%) received radiation, 46 (23%) cranial radiation, and 69 (35%) high-dose methotrexate. Most prevalent CTCAE Grades 3–4 (severe life-threatening) conditions were obesity (35%), hypertension (9%), and impairment of executive function (13%), attention (9%), and memory (4%). Many had impaired strength (48%), flexibility (39%), muscular endurance (36%), and mobility (36%). Demographic and treatment-related factors were associated with the development of individual chronic diseases and functional deficits. Conclusions: Clinical evaluation identified a high prevalence of chronic health conditions, neurocognitive deficits, and performance limitations in childhood NHL survivors.
KW - chronic health conditions
KW - late effects
KW - neurocognitive
KW - non-Hodgkin lymphoma
KW - survivorship
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U2 - 10.1002/pbc.26338
DO - 10.1002/pbc.26338
M3 - Article
C2 - 27860222
AN - SCOPUS:85006054272
SN - 1545-5009
VL - 64
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 6
M1 - e26338
ER -