Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Jonathan Miller; Andrew J. Watrous; Melina Tsitsiklis; Sang Ah Lee; Sameer A. Sheth; Catherine A. Schevon; Elliot H. Smith; Michael R. Sperling; Ashwini Sharan; Ali Akbar Asadi-Pooya; Gregory A. Worrell; Stephen Meisenhelter; Cory S. Inman; Kathryn A. Davis; Bradley Lega; Paul A. Wanda; Sandhitsu R. Das; Joel M. Stein; Richard Gorniak; Joshua Jacobs

doi:10.1038/s41467-018-04847-9

Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Jonathan Miller, Andrew J. Watrous, Melina Tsitsiklis, Sang Ah Lee, Sameer A. Sheth, Catherine A. Schevon, Elliot H. Smith, Michael R. Sperling, Ashwini Sharan, Ali Akbar Asadi-Pooya, Gregory A. Worrell, Stephen Meisenhelter, Cory S. Inman, Kathryn A. Davis, Bradley Lega, Paul A. Wanda, Sandhitsu R. Das, Joel M. Stein, Richard Gorniak, Joshua Jacobs

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Abstract

The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1-3-Hz "low theta" band increases when viewing subsequently remembered object-location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.

Original language	English (US)
Article number	2423
Journal	Nature communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-04847-9
State	Published - Dec 1 2018

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Miller, J., Watrous, A. J., Tsitsiklis, M., Lee, S. A., Sheth, S. A., Schevon, C. A., Smith, E. H., Sperling, M. R., Sharan, A., Asadi-Pooya, A. A., Worrell, G. A., Meisenhelter, S., Inman, C. S., Davis, K. A., Lega, B., Wanda, P. A., Das, S. R., Stein, J. M., Gorniak, R., & Jacobs, J. (2018). Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. Nature communications, 9(1), Article 2423. https://doi.org/10.1038/s41467-018-04847-9

Miller, J, Watrous, AJ, Tsitsiklis, M, Lee, SA, Sheth, SA, Schevon, CA, Smith, EH, Sperling, MR, Sharan, A, Asadi-Pooya, AA, Worrell, GA, Meisenhelter, S, Inman, CS, Davis, KA, Lega, B, Wanda, PA, Das, SR, Stein, JM, Gorniak, R & Jacobs, J 2018, 'Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation', Nature communications, vol. 9, no. 1, 2423. https://doi.org/10.1038/s41467-018-04847-9

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abstract = "The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1-3-Hz {"}low theta{"} band increases when viewing subsequently remembered object-location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.",

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AU - Asadi-Pooya, Ali Akbar

AU - Worrell, Gregory A.

AU - Meisenhelter, Stephen

AU - Inman, Cory S.

AU - Davis, Kathryn A.

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AU - Wanda, Paul A.

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AU - Gorniak, Richard

AU - Jacobs, Joshua

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Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Abstract

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