Latex carrier for improving protoporphyrin IX for photodynamic therapy

Brian Bui, Li Liu, Wei Chen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalPhotodiagnosis and Photodynamic Therapy
Volume14
DOIs
StatePublished - Jun 1 2016

Keywords

  • Latex carrier
  • Photodynamic therapy (PDT)
  • Protoporphyrin (PPIX)

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)

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