@article{43fb3e6bf6e8457d87a4d057c627a5a7,
title = "Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription",
abstract = "Li et al. identify a key role of Lats1/2 kinases during intestinal homeostasis for maintaining Wnt pathway activity and intestinal stem cells. Using a selective small-molecule inhibitor of TEAD auto-palmitoylation, they reveal both TEAD-dependent and independent transcriptional regulation downstream of YAP/TAZ in intestinal epithelium.",
keywords = "Lats1/2, TEAD, Wnt, intestinal stemness, palmitoylation inhibitor, tumorigenesis",
author = "Qi Li and Yang Sun and Jarugumilli, {Gopala K.} and Shun Liu and Kyvan Dang and Cotton, {Jennifer L.} and Jordi Xiol and Chan, {Pui Yee} and Michael DeRan and Lifang Ma and Rui Li and Zhu, {Lihua J.} and Li, {Joyce H.} and Leiter, {Andrew B.} and Ip, {Y. Tony} and Camargo, {Fernando D.} and Xuelian Luo and Johnson, {Randy L.} and Xu Wu and Junhao Mao",
note = "Funding Information: This work was supported by grants from the National Institutes of Health R01DK099510 to J.M., R01CA238270 to X.W. and J.M., R01CA181537 to X.W., R01DK107651 to X.W and X.L., the Welch Foundation Award ( I-1932 ) to X.L., and Samuel M. Fisher Memorial MRA (Melanoma Research Alliance) Established Investigator Award to X.W. We also thank Xiao Han for help with protein crystallization and the members of Wu lab and Mao lab for helpful discussion. Funding Information: This work was supported by grants from the National Institutes of Health R01DK099510 to J.M. R01CA238270 to X.W. and J.M. R01CA181537 to X.W. R01DK107651 to X.W and X.L. the Welch Foundation Award (I-1932) to X.L. and Samuel M. Fisher Memorial MRA (Melanoma Research Alliance) Established Investigator Award to X.W. We also thank Xiao Han for help with protein crystallization and the members of Wu lab and Mao lab for helpful discussion. Q.L. Y.S. G.K.J. X.W. and J.M. designed the study. Q.L. Y.S. G.K.J. S.L. K.D. J.L.C. J.X. P.Y.C. M.D. and L.M. acquired data. R.L. and L.J.Z. performed bioinformatics analysis. J.H.L. A.B.L. Y.T.I. and R.L.J. provide important resources. F.D.C. X.L. X.W. and J.M. interpreted data. X.W. and J.M. supervised the study and wrote the paper. Massachusetts General Hospital holds a patent of MGH-CP1 as a TEAD inhibitor. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = may,
day = "7",
doi = "10.1016/j.stem.2020.03.002",
language = "English (US)",
volume = "26",
pages = "675--692.e8",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "5",
}