Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Qi Li, Yang Sun, Gopala K. Jarugumilli, Shun Liu, Kyvan Dang, Jennifer L. Cotton, Jordi Xiol, Pui Yee Chan, Michael DeRan, Lifang Ma, Rui Li, Lihua J. Zhu, Joyce H. Li, Andrew B. Leiter, Y. Tony Ip, Fernando D. Camargo, Xuelian Luo, Randy L. Johnson, Xu Wu, Junhao Mao

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Li et al. identify a key role of Lats1/2 kinases during intestinal homeostasis for maintaining Wnt pathway activity and intestinal stem cells. Using a selective small-molecule inhibitor of TEAD auto-palmitoylation, they reveal both TEAD-dependent and independent transcriptional regulation downstream of YAP/TAZ in intestinal epithelium.

Original languageEnglish (US)
Pages (from-to)675-692.e8
JournalCell Stem Cell
Volume26
Issue number5
DOIs
StatePublished - May 7 2020

Keywords

  • Lats1/2
  • TEAD
  • Wnt
  • intestinal stemness
  • palmitoylation inhibitor
  • tumorigenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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