Abstract
Mice pretreated with the LC-9018 showed enhanced survival compared to controls when burned and infected with P. aeruginosa and K. pneumoniae strains. Burned skin quantitative bacterial counts in LC-9018 treated and controls were similar but kidney and liver counts of treated mice were significantly lower. Increased peritoneal cell counts in LC-9018 treated groups suggested enhanced survival and lower organ counts resulted from increased microbial clearance. Survival in LC-9018 pretreated P. aeruginosa infected burned mice was reduced in neutropenic or macrophage blockaded mice which supported this hypothesis. Burned mice treated with LC-9018 at times postburn but pre-P. aeruginosa infection showed significantly enhanced survival. Thus LC-9018 treatment might be useful for increasing survival from burn wound sepsis and further investigation is warranted.
Original language | English (US) |
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Pages (from-to) | 247-253 |
Number of pages | 7 |
Journal | International Journal of Antimicrobial Agents |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 1993 |
Keywords
- Biological response modifier
- Burn infection
- LC-9018
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)