LDL cholesterol: Should guidelines include targets?

Subhash Banerjee, Dhiman Kahali, Avantika Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of target-based LDL-C lowering to reduce the risk of coronary heart disease and secondary event rates is now well established. However, the strategy for treating to a target LDL-C, and whether there is a lower threshold level for LDL-C continues to be debated. We present, and critically analyze the evidence for a target-based LDL-C lowering strategy, and the safety and efficacy of intensive plasma LDL-C-lowering with traditional, and novel LDL-lowering therapies below current guideline targets.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalExpert Review of Cardiovascular Therapy
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2014

Keywords

  • LDL-C
  • lipid lowering therapy
  • treatment targets

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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