LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

Joachim Herz, David E. Clouthier, Robert E Hammer

Research output: Contribution to journalArticle

467 Scopus citations

Abstract

The low density lipoprotein receptor-related protein (LRP) is a large multifunctional clearance receptor that has been implicated in the hepatic uptake of chylomicron remnants and in the removal of protease-inhibitor complexes from the circulation and from the extracellular space. Disruption of the LRP gene in mice blocks development of LRP-/- embryos around the implantation stage. The expression pattern of LRP in the postimplantation stage embryo is identical to that of urokinase, a plasminogen activator that confers invasive properties to migrating cells. We demonstrate that LRP mediates uptake and degradation of urokinase-type plasminogen activator-plasminogen activator inhibitor 1 complexes and propose that the inability of the giant cells to remove the inactive protease complexes from their surfaces interferes with implantation of the embryo.

Original languageEnglish (US)
Pages (from-to)411-421
Number of pages11
JournalCell
Volume71
Issue number3
DOIs
StatePublished - Oct 30 1992

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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