Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Ramesh Gujjar, Farah El Mazouni, Karen L. White, John White, Sharon Creason, David M. Shackleford, Xiaoyi Deng, William N. Charman, Ian Bathurst, Jeremy Burrows, David M. Floyd, David Matthews, Frederick S. Buckner, Susan A. Charman, Margaret A. Phillips, Pradipsinh K. Rathod