Learning and memory difficulties after environmental exposure to waterways containing toxin-producing Pfiesteria or Pfiesteria-like dinoflagellates

Lynn M. Grattan, David Oldach, Trish M. Perl, Mark H. Lowitt, Diane L. Matuszak, Curtis Dickson, Colleen Parrott, Ritchie C. Shoemaker, C. Lisa Kauffman, Martin P. Wasserman, J. Richard Hebel, Patricia Charache, J. Glenn Morris

Research output: Contribution to journalArticle

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Abstract

Background. At the beginning of autumn, 1996, fish with 'punched-out' skin lesions and erratic behaviour associated with exposure to toxins produced by Pfiesteria piscicida or Pfiesteria-like dinoflagellate species were seen in the Pocomoke River and adjacent waterways on the eastern shore of the Chesapeake Bay in Maryland, USA. In August, 1997, fish kills associated with Pfiesteria occurred in these same areas. People who had had contact with affected waterways reported symptoms, including memory difficulties, which raises questions about the human-health impact of environmental exposure to Pfiesteria toxins. Methods. We assessed 24 people who had been exposed. We collected data on exposure history and symptoms, did a complete medical and laboratory assessment (13 people), and carried out a neuropsychological screening battery. Performance on neuropsychological measures was compared with a matched control group. Results. People with high exposure were significantly more likely than occupationally matched controls to complain of neuropsychological symptoms (including new or increased forgetfulness); headache; and skin lesions or a burning sensation of shin on contact with water. No consistent physical or laboratory abnormalities were found. However, exposed people had significantly reduced scores on the Rey Auditory Verbal Learning and Stroop Color-Word tests (indicative of difficulties with learning and higher cognitive function), and the Grooved Pegboard task. There was a dose-response effect with the lowest scores among people with the highest exposure. By 3-6 months after cessation of exposure, all those assessed had test scores that had returned to within normal ranges. Interpretation. People with environmental exposure to waterways in which Pfiesteria toxins are present are at risk of developing a reversible clinical syndrome characterised by difficulties with learning and higher cognitive functions. Risk of illness is directly related to degree of exposure, with the most prominent symptoms and signs occurring among people with chronic daily exposure to affected waterways.

Original languageEnglish (US)
Pages (from-to)532-539
Number of pages8
JournalLancet
Volume352
Issue number9127
DOIs
StatePublished - Aug 15 1998

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Dinoflagellida
Environmental Exposure
Cognition
Pfiesteria piscicida
Fishes
Learning
Verbal Learning
Skin
Rivers
Signs and Symptoms
Headache
Reference Values
Research Design
Color
History
Control Groups
Water
Health

ASJC Scopus subject areas

  • Medicine(all)

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Learning and memory difficulties after environmental exposure to waterways containing toxin-producing Pfiesteria or Pfiesteria-like dinoflagellates. / Grattan, Lynn M.; Oldach, David; Perl, Trish M.; Lowitt, Mark H.; Matuszak, Diane L.; Dickson, Curtis; Parrott, Colleen; Shoemaker, Ritchie C.; Kauffman, C. Lisa; Wasserman, Martin P.; Hebel, J. Richard; Charache, Patricia; Morris, J. Glenn.

In: Lancet, Vol. 352, No. 9127, 15.08.1998, p. 532-539.

Research output: Contribution to journalArticle

Grattan, LM, Oldach, D, Perl, TM, Lowitt, MH, Matuszak, DL, Dickson, C, Parrott, C, Shoemaker, RC, Kauffman, CL, Wasserman, MP, Hebel, JR, Charache, P & Morris, JG 1998, 'Learning and memory difficulties after environmental exposure to waterways containing toxin-producing Pfiesteria or Pfiesteria-like dinoflagellates', Lancet, vol. 352, no. 9127, pp. 532-539. https://doi.org/10.1016/S0140-6736(98)02132-1
Grattan, Lynn M. ; Oldach, David ; Perl, Trish M. ; Lowitt, Mark H. ; Matuszak, Diane L. ; Dickson, Curtis ; Parrott, Colleen ; Shoemaker, Ritchie C. ; Kauffman, C. Lisa ; Wasserman, Martin P. ; Hebel, J. Richard ; Charache, Patricia ; Morris, J. Glenn. / Learning and memory difficulties after environmental exposure to waterways containing toxin-producing Pfiesteria or Pfiesteria-like dinoflagellates. In: Lancet. 1998 ; Vol. 352, No. 9127. pp. 532-539.
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abstract = "Background. At the beginning of autumn, 1996, fish with 'punched-out' skin lesions and erratic behaviour associated with exposure to toxins produced by Pfiesteria piscicida or Pfiesteria-like dinoflagellate species were seen in the Pocomoke River and adjacent waterways on the eastern shore of the Chesapeake Bay in Maryland, USA. In August, 1997, fish kills associated with Pfiesteria occurred in these same areas. People who had had contact with affected waterways reported symptoms, including memory difficulties, which raises questions about the human-health impact of environmental exposure to Pfiesteria toxins. Methods. We assessed 24 people who had been exposed. We collected data on exposure history and symptoms, did a complete medical and laboratory assessment (13 people), and carried out a neuropsychological screening battery. Performance on neuropsychological measures was compared with a matched control group. Results. People with high exposure were significantly more likely than occupationally matched controls to complain of neuropsychological symptoms (including new or increased forgetfulness); headache; and skin lesions or a burning sensation of shin on contact with water. No consistent physical or laboratory abnormalities were found. However, exposed people had significantly reduced scores on the Rey Auditory Verbal Learning and Stroop Color-Word tests (indicative of difficulties with learning and higher cognitive function), and the Grooved Pegboard task. There was a dose-response effect with the lowest scores among people with the highest exposure. By 3-6 months after cessation of exposure, all those assessed had test scores that had returned to within normal ranges. Interpretation. People with environmental exposure to waterways in which Pfiesteria toxins are present are at risk of developing a reversible clinical syndrome characterised by difficulties with learning and higher cognitive functions. Risk of illness is directly related to degree of exposure, with the most prominent symptoms and signs occurring among people with chronic daily exposure to affected waterways.",
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T1 - Learning and memory difficulties after environmental exposure to waterways containing toxin-producing Pfiesteria or Pfiesteria-like dinoflagellates

AU - Grattan, Lynn M.

AU - Oldach, David

AU - Perl, Trish M.

AU - Lowitt, Mark H.

AU - Matuszak, Diane L.

AU - Dickson, Curtis

AU - Parrott, Colleen

AU - Shoemaker, Ritchie C.

AU - Kauffman, C. Lisa

AU - Wasserman, Martin P.

AU - Hebel, J. Richard

AU - Charache, Patricia

AU - Morris, J. Glenn

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Y1 - 1998/8/15

N2 - Background. At the beginning of autumn, 1996, fish with 'punched-out' skin lesions and erratic behaviour associated with exposure to toxins produced by Pfiesteria piscicida or Pfiesteria-like dinoflagellate species were seen in the Pocomoke River and adjacent waterways on the eastern shore of the Chesapeake Bay in Maryland, USA. In August, 1997, fish kills associated with Pfiesteria occurred in these same areas. People who had had contact with affected waterways reported symptoms, including memory difficulties, which raises questions about the human-health impact of environmental exposure to Pfiesteria toxins. Methods. We assessed 24 people who had been exposed. We collected data on exposure history and symptoms, did a complete medical and laboratory assessment (13 people), and carried out a neuropsychological screening battery. Performance on neuropsychological measures was compared with a matched control group. Results. People with high exposure were significantly more likely than occupationally matched controls to complain of neuropsychological symptoms (including new or increased forgetfulness); headache; and skin lesions or a burning sensation of shin on contact with water. No consistent physical or laboratory abnormalities were found. However, exposed people had significantly reduced scores on the Rey Auditory Verbal Learning and Stroop Color-Word tests (indicative of difficulties with learning and higher cognitive function), and the Grooved Pegboard task. There was a dose-response effect with the lowest scores among people with the highest exposure. By 3-6 months after cessation of exposure, all those assessed had test scores that had returned to within normal ranges. Interpretation. People with environmental exposure to waterways in which Pfiesteria toxins are present are at risk of developing a reversible clinical syndrome characterised by difficulties with learning and higher cognitive functions. Risk of illness is directly related to degree of exposure, with the most prominent symptoms and signs occurring among people with chronic daily exposure to affected waterways.

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