Lecithin-sphingomyelin ratios in amniotic fluid of pregnancies with an anencephalic fetus

C. R. Parker, K. J. Leveno, L. Milewich, P. C. MacDonald

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

As many investigators have shown that surfactant production in the developing human lung is subject to multihormonal regulation, the present authors determined the lecithin-sphingomyelin (L/S) ratio in amniotic fluid of pregnancies with an anencephalic fetus, in which there was known to be aberrant production of fetal pituitary, adrenal, and consequently, placental hormones. The L/S ratio in amniotic fluid from seven of eight pregnancies with an anencephalic fetus was substantially lower than that in amniotic fluids of pregnancies with a normal fetus at the same stage of gestation. The L/S ratio in amniotic fluid of an anencephalic fetus of a twin pregnancy (monochorionic diamniotic) at 34 weeks' gestation was low; the L/S ratio of the amniotic fluid of the normal fetus was high. These data are supportive of the view that fetal lung maturation is dependent, in part, upon normal function of the fetal pituitary and adrenal.

Original languageEnglish (US)
Pages (from-to)546-549
Number of pages4
JournalObstetrics and gynecology
Volume68
Issue number4
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Parker, C. R., Leveno, K. J., Milewich, L., & MacDonald, P. C. (1986). Lecithin-sphingomyelin ratios in amniotic fluid of pregnancies with an anencephalic fetus. Obstetrics and gynecology, 68(4), 546-549.