Lecithin/sphingomyelin ratio and lamellar body count: What values predict the presence of phosphatidylglycerol?

Sarah H. Poggi, Catherine Y. Spong, John C. Pezzullo, Patricia Z. Bannon, Katie M. Goodwin, Joy Vink, Alessandro Ghidini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG). STUDY DESIGN: A database of clear amniotic fluid specimens obtained by amniocentesis was accessed. Receiver operating characteristic curve analysis was performed for both L/S ratio and LBC to identify the optimal thresholds for predicting the presence of PG. RESULTS: One hundred eighty-eight patients were included in the analysis. "Trace" PG was more like "absent" PG in relation to both L/S ratio and LBC. There were significant relationships between L/S ratios and presence of PG (area under the curve =.909, P <.0001) and between LBC and presence of PG (area under the curve = .94, P <.0001). The positive predictive value of L/S ratio > 2 was 76%, and that of LBC > 30,000 was 82% in predicting the presence of PG. Optimal threshold values for the prediction of PG presence were > 3.0 for L/S ratio, which had a positive predictive value of 95% and false positive rate of 5%, and > 50,000 for LBC, with a 96% positive predictive value and 5% false positive rate. CONCLUSION: "Mature" results for PG in amniotic fluid are equivalent to an L/S ratio of > 3.0 and LBC > 50,000 and help explain the later gestational age at the appearance of lung maturity by PG than by L/S > 2 or LBC > 30,000.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume48
Issue number5
StatePublished - May 1 2003
Externally publishedYes

Fingerprint

Phosphatidylglycerols
Sphingomyelins
Lecithins
Amniotic Fluid
Amniocentesis
ROC Curve
Gestational Age
Area Under Curve
Databases
Lung

Keywords

  • Lamellar body count
  • Lecithins
  • Phosphatidylglycerol
  • Respiratory distress syndrome
  • Sphingomyelins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Lecithin/sphingomyelin ratio and lamellar body count : What values predict the presence of phosphatidylglycerol? / Poggi, Sarah H.; Spong, Catherine Y.; Pezzullo, John C.; Bannon, Patricia Z.; Goodwin, Katie M.; Vink, Joy; Ghidini, Alessandro.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 48, No. 5, 01.05.2003, p. 330-334.

Research output: Contribution to journalArticle

Poggi, Sarah H. ; Spong, Catherine Y. ; Pezzullo, John C. ; Bannon, Patricia Z. ; Goodwin, Katie M. ; Vink, Joy ; Ghidini, Alessandro. / Lecithin/sphingomyelin ratio and lamellar body count : What values predict the presence of phosphatidylglycerol?. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2003 ; Vol. 48, No. 5. pp. 330-334.
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abstract = "OBJECTIVE: To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG). STUDY DESIGN: A database of clear amniotic fluid specimens obtained by amniocentesis was accessed. Receiver operating characteristic curve analysis was performed for both L/S ratio and LBC to identify the optimal thresholds for predicting the presence of PG. RESULTS: One hundred eighty-eight patients were included in the analysis. {"}Trace{"} PG was more like {"}absent{"} PG in relation to both L/S ratio and LBC. There were significant relationships between L/S ratios and presence of PG (area under the curve =.909, P <.0001) and between LBC and presence of PG (area under the curve = .94, P <.0001). The positive predictive value of L/S ratio > 2 was 76{\%}, and that of LBC > 30,000 was 82{\%} in predicting the presence of PG. Optimal threshold values for the prediction of PG presence were > 3.0 for L/S ratio, which had a positive predictive value of 95{\%} and false positive rate of 5{\%}, and > 50,000 for LBC, with a 96{\%} positive predictive value and 5{\%} false positive rate. CONCLUSION: {"}Mature{"} results for PG in amniotic fluid are equivalent to an L/S ratio of > 3.0 and LBC > 50,000 and help explain the later gestational age at the appearance of lung maturity by PG than by L/S > 2 or LBC > 30,000.",
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T2 - What values predict the presence of phosphatidylglycerol?

AU - Poggi, Sarah H.

AU - Spong, Catherine Y.

AU - Pezzullo, John C.

AU - Bannon, Patricia Z.

AU - Goodwin, Katie M.

AU - Vink, Joy

AU - Ghidini, Alessandro

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N2 - OBJECTIVE: To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG). STUDY DESIGN: A database of clear amniotic fluid specimens obtained by amniocentesis was accessed. Receiver operating characteristic curve analysis was performed for both L/S ratio and LBC to identify the optimal thresholds for predicting the presence of PG. RESULTS: One hundred eighty-eight patients were included in the analysis. "Trace" PG was more like "absent" PG in relation to both L/S ratio and LBC. There were significant relationships between L/S ratios and presence of PG (area under the curve =.909, P <.0001) and between LBC and presence of PG (area under the curve = .94, P <.0001). The positive predictive value of L/S ratio > 2 was 76%, and that of LBC > 30,000 was 82% in predicting the presence of PG. Optimal threshold values for the prediction of PG presence were > 3.0 for L/S ratio, which had a positive predictive value of 95% and false positive rate of 5%, and > 50,000 for LBC, with a 96% positive predictive value and 5% false positive rate. CONCLUSION: "Mature" results for PG in amniotic fluid are equivalent to an L/S ratio of > 3.0 and LBC > 50,000 and help explain the later gestational age at the appearance of lung maturity by PG than by L/S > 2 or LBC > 30,000.

AB - OBJECTIVE: To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG). STUDY DESIGN: A database of clear amniotic fluid specimens obtained by amniocentesis was accessed. Receiver operating characteristic curve analysis was performed for both L/S ratio and LBC to identify the optimal thresholds for predicting the presence of PG. RESULTS: One hundred eighty-eight patients were included in the analysis. "Trace" PG was more like "absent" PG in relation to both L/S ratio and LBC. There were significant relationships between L/S ratios and presence of PG (area under the curve =.909, P <.0001) and between LBC and presence of PG (area under the curve = .94, P <.0001). The positive predictive value of L/S ratio > 2 was 76%, and that of LBC > 30,000 was 82% in predicting the presence of PG. Optimal threshold values for the prediction of PG presence were > 3.0 for L/S ratio, which had a positive predictive value of 95% and false positive rate of 5%, and > 50,000 for LBC, with a 96% positive predictive value and 5% false positive rate. CONCLUSION: "Mature" results for PG in amniotic fluid are equivalent to an L/S ratio of > 3.0 and LBC > 50,000 and help explain the later gestational age at the appearance of lung maturity by PG than by L/S > 2 or LBC > 30,000.

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