Abstract
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL. Increased expression of LOX-1 has been demonstrated in atherosclerotic lesions and diabetic vasculopathy. In this study, we investigate the expression of LOX-1 receptor in sickle cell disease (SCD) vasculopathy. Expression of LOX-1 in brain vascular endothelium is markedly increased and LOX-1 gene expression is upregulated in cultured human brain microvascular endothelial cells by incubation with SCD erythrocytes. Also, the level of circulating soluble LOX-1 concentration is elevated in the plasma of SCD patients. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of SCD vasculopathy. Soluble LOX-1 concentration in SCD may provide a novel biomarker for risk stratification of sickle cell vascular complications.
Original language | English (US) |
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Pages (from-to) | 44-48 |
Number of pages | 5 |
Journal | Blood Cells, Molecules, and Diseases |
Volume | 60 |
DOIs | |
State | Published - Sep 1 2016 |
Keywords
- Adhesion molecule
- Endothelium
- Lectin-like oxidized low-density lipoprotein receptor (LOX-1)
- Sickle cell disease
- Vasculopathy
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Hematology
- Cell Biology