Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy

Mingyi Chen, Hong Qiu, Xin Lin, David Nam, Lucy Ogbu-Nwobodo, Hannah Archibald, Amelia Joslin, Ted Wun, Tatsuya Sawamura, Ralph Green

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL. Increased expression of LOX-1 has been demonstrated in atherosclerotic lesions and diabetic vasculopathy. In this study, we investigate the expression of LOX-1 receptor in sickle cell disease (SCD) vasculopathy. Expression of LOX-1 in brain vascular endothelium is markedly increased and LOX-1 gene expression is upregulated in cultured human brain microvascular endothelial cells by incubation with SCD erythrocytes. Also, the level of circulating soluble LOX-1 concentration is elevated in the plasma of SCD patients. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of SCD vasculopathy. Soluble LOX-1 concentration in SCD may provide a novel biomarker for risk stratification of sickle cell vascular complications.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume60
DOIs
StatePublished - Sep 1 2016

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Class E Scavenger Receptors
Sickle Cell Anemia
Endothelial Cells
Vascular Endothelium
Brain
Plasma Cells
Blood Vessels
Erythrocytes
Biomarkers
Gene Expression

Keywords

  • Adhesion molecule
  • Endothelium
  • Lectin-like oxidized low-density lipoprotein receptor (LOX-1)
  • Sickle cell disease
  • Vasculopathy

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Molecular Biology
  • Cell Biology

Cite this

Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy. / Chen, Mingyi; Qiu, Hong; Lin, Xin; Nam, David; Ogbu-Nwobodo, Lucy; Archibald, Hannah; Joslin, Amelia; Wun, Ted; Sawamura, Tatsuya; Green, Ralph.

In: Blood Cells, Molecules, and Diseases, Vol. 60, 01.09.2016, p. 44-48.

Research output: Contribution to journalArticle

Chen, M, Qiu, H, Lin, X, Nam, D, Ogbu-Nwobodo, L, Archibald, H, Joslin, A, Wun, T, Sawamura, T & Green, R 2016, 'Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy', Blood Cells, Molecules, and Diseases, vol. 60, pp. 44-48. https://doi.org/10.1016/j.bcmd.2016.06.005
Chen, Mingyi ; Qiu, Hong ; Lin, Xin ; Nam, David ; Ogbu-Nwobodo, Lucy ; Archibald, Hannah ; Joslin, Amelia ; Wun, Ted ; Sawamura, Tatsuya ; Green, Ralph. / Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy. In: Blood Cells, Molecules, and Diseases. 2016 ; Vol. 60. pp. 44-48.
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AU - Joslin, Amelia

AU - Wun, Ted

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