Left hemisphere regions are critical for language in the face of early left focal brain injury

Anjali Raja Beharelle, Anthony Steven Dick, Goulven Josse, Ana Solodkin, Peter R. Huttenlocher, Susan C. Levine, Steven L. Small

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A predominant theory regarding early stroke and its effect on language development, is that early left hemisphere lesions trigger compensatory processes that allow the right hemisphere to assume dominant language functions, and this is thought to underlie the near normal language development observed after early stroke. To test this theory, we used functional magnetic resonance imaging to examine brain activity during category fluency in participants who had sustained pre-or perinatal left hemisphere stroke (n = 25) and in neurologically normal siblings (n = 27). In typically developing children, performance of a category fluency task elicits strong involvement of left frontal and lateral temporal regions and a lesser involvement of right hemisphere structures. In our cohort of atypically developing participants with early stroke, expressive and receptive language skills correlated with activity in the same left inferior frontal regions that support language processing in neurologically normal children. This was true independent of either the amount of brain injury or the extent that the injury was located in classical cortical language processing areas. Participants with bilateral activation in left and right superior temporal-inferior parietal regions had better language function than those with either predominantly left-or right-sided unilateral activation. The advantage conferred by left inferior frontal and bilateral temporal involvement demonstrated in our study supports a strong predisposition for typical neural language organization, despite an intervening injury, and argues against models suggesting that the right hemisphere fully accommodates language function following early injury.

Original languageEnglish (US)
Pages (from-to)1707-1716
Number of pages10
JournalBrain
Volume133
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Brain Injuries
Language
Stroke
Language Development
Wounds and Injuries
Parietal Lobe
Temporal Lobe
Siblings
Magnetic Resonance Imaging
Organizations
Brain

Keywords

  • Development
  • Functional organization
  • Language
  • Plasticity
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Raja Beharelle, A., Dick, A. S., Josse, G., Solodkin, A., Huttenlocher, P. R., Levine, S. C., & Small, S. L. (2010). Left hemisphere regions are critical for language in the face of early left focal brain injury. Brain, 133(6), 1707-1716. https://doi.org/10.1093/brain/awq104

Left hemisphere regions are critical for language in the face of early left focal brain injury. / Raja Beharelle, Anjali; Dick, Anthony Steven; Josse, Goulven; Solodkin, Ana; Huttenlocher, Peter R.; Levine, Susan C.; Small, Steven L.

In: Brain, Vol. 133, No. 6, 06.2010, p. 1707-1716.

Research output: Contribution to journalArticle

Raja Beharelle, A, Dick, AS, Josse, G, Solodkin, A, Huttenlocher, PR, Levine, SC & Small, SL 2010, 'Left hemisphere regions are critical for language in the face of early left focal brain injury', Brain, vol. 133, no. 6, pp. 1707-1716. https://doi.org/10.1093/brain/awq104
Raja Beharelle A, Dick AS, Josse G, Solodkin A, Huttenlocher PR, Levine SC et al. Left hemisphere regions are critical for language in the face of early left focal brain injury. Brain. 2010 Jun;133(6):1707-1716. https://doi.org/10.1093/brain/awq104
Raja Beharelle, Anjali ; Dick, Anthony Steven ; Josse, Goulven ; Solodkin, Ana ; Huttenlocher, Peter R. ; Levine, Susan C. ; Small, Steven L. / Left hemisphere regions are critical for language in the face of early left focal brain injury. In: Brain. 2010 ; Vol. 133, No. 6. pp. 1707-1716.
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