Left ventricular hypertrophy associated with chronic cocaine abuse

M. Elizabeth Brickner, John E. Willard, Eric J. Eichhorn, John Black, Paul A. Grayburn

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Background. This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. Methods and Results. A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. Subjects with elevated resting blood pressure (n=4) or a history of hypertension (n=3) were excluded. Technically adequate two-dimensional echocardiograms were obtained in 30 cocaine abusers and 30 age- and race-matched normal control subjects. All subjects were men, and the groups were similar with regard to resting blood pressure, height, weight, and body surface area. All echocardiograms were read in blinded fashion, and left ventricular mass was calculated by the area-length method. Left ventricular cavity dimensions and wall motion were normal in all subjects. Left ventricular mass index was higher in the cocaine group (103±24 versus 77±14 g/m2, p=0.0001). Posterior wall thickness was increased (1.2 cm or more) in 13 cocaine abusers (43%) compared with four controls (p=0.0099). Conclusions. Chronic cocaine abuse is associated with increased left ventricular mass index and wall thickness. Left ventricular hypertrophy may provide a substrate facilitating the development of myocardial ischemia and/or arrhythmias in cocaine abusers.

Original languageEnglish (US)
Pages (from-to)1130-1135
Number of pages6
JournalCirculation
Volume84
Issue number3
StatePublished - Sep 1991

Fingerprint

Cocaine-Related Disorders
Left Ventricular Hypertrophy
Cocaine
Blood Pressure
Body Surface Area
Myocardial Ischemia
Cardiac Arrhythmias
Inpatients
Rehabilitation
Hypertension
Weights and Measures
Pharmaceutical Preparations

Keywords

  • Cocaine
  • Echocardiography
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Brickner, M. E., Willard, J. E., Eichhorn, E. J., Black, J., & Grayburn, P. A. (1991). Left ventricular hypertrophy associated with chronic cocaine abuse. Circulation, 84(3), 1130-1135.

Left ventricular hypertrophy associated with chronic cocaine abuse. / Brickner, M. Elizabeth; Willard, John E.; Eichhorn, Eric J.; Black, John; Grayburn, Paul A.

In: Circulation, Vol. 84, No. 3, 09.1991, p. 1130-1135.

Research output: Contribution to journalArticle

Brickner, ME, Willard, JE, Eichhorn, EJ, Black, J & Grayburn, PA 1991, 'Left ventricular hypertrophy associated with chronic cocaine abuse', Circulation, vol. 84, no. 3, pp. 1130-1135.
Brickner ME, Willard JE, Eichhorn EJ, Black J, Grayburn PA. Left ventricular hypertrophy associated with chronic cocaine abuse. Circulation. 1991 Sep;84(3):1130-1135.
Brickner, M. Elizabeth ; Willard, John E. ; Eichhorn, Eric J. ; Black, John ; Grayburn, Paul A. / Left ventricular hypertrophy associated with chronic cocaine abuse. In: Circulation. 1991 ; Vol. 84, No. 3. pp. 1130-1135.
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N2 - Background. This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. Methods and Results. A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. Subjects with elevated resting blood pressure (n=4) or a history of hypertension (n=3) were excluded. Technically adequate two-dimensional echocardiograms were obtained in 30 cocaine abusers and 30 age- and race-matched normal control subjects. All subjects were men, and the groups were similar with regard to resting blood pressure, height, weight, and body surface area. All echocardiograms were read in blinded fashion, and left ventricular mass was calculated by the area-length method. Left ventricular cavity dimensions and wall motion were normal in all subjects. Left ventricular mass index was higher in the cocaine group (103±24 versus 77±14 g/m2, p=0.0001). Posterior wall thickness was increased (1.2 cm or more) in 13 cocaine abusers (43%) compared with four controls (p=0.0099). Conclusions. Chronic cocaine abuse is associated with increased left ventricular mass index and wall thickness. Left ventricular hypertrophy may provide a substrate facilitating the development of myocardial ischemia and/or arrhythmias in cocaine abusers.

AB - Background. This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. Methods and Results. A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. Subjects with elevated resting blood pressure (n=4) or a history of hypertension (n=3) were excluded. Technically adequate two-dimensional echocardiograms were obtained in 30 cocaine abusers and 30 age- and race-matched normal control subjects. All subjects were men, and the groups were similar with regard to resting blood pressure, height, weight, and body surface area. All echocardiograms were read in blinded fashion, and left ventricular mass was calculated by the area-length method. Left ventricular cavity dimensions and wall motion were normal in all subjects. Left ventricular mass index was higher in the cocaine group (103±24 versus 77±14 g/m2, p=0.0001). Posterior wall thickness was increased (1.2 cm or more) in 13 cocaine abusers (43%) compared with four controls (p=0.0099). Conclusions. Chronic cocaine abuse is associated with increased left ventricular mass index and wall thickness. Left ventricular hypertrophy may provide a substrate facilitating the development of myocardial ischemia and/or arrhythmias in cocaine abusers.

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