TY - JOUR
T1 - Left ventricular morphology and function in adolescents
T2 - Relations to fitness and fatness
AU - Dias, Katrin A.
AU - Spence, Angela L.
AU - Sarma, Satyam
AU - Oxborough, David
AU - Timilsina, Anita S.
AU - Davies, Peter S.W.
AU - Cain, Peter A.
AU - Leong, Gary M.
AU - Ingul, Charlotte B.
AU - Coombes, Jeff S.
N1 - Funding Information:
This work was supported by St Olav's Hospital and The Norwegian University of Science and Technology [grant number #9527], Sports Medicine Australia Research Foundation, and The Wesley and St Andrew's Research Institute [grant number #2014-01].
Publisher Copyright:
© 2017
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature all-cause mortality. The aim of this study was to determine differences in LV morphology and function in obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory fitness (CRF) and adiposity were explored. Methods LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normal-weight [BMI equivalent to 18 kg/m2–25 kg/m2] and 9 obese [BMI equivalent to ≥ 30 kg/m2]); 13.3 ± 1.1 years, 45% female, Tanner puberty stage 3 [2–4]) using magnetic resonance imaging (MRI). Global longitudinal strain (GLS), strain rate (SR) and traditional echocardiographic indices were used to assess LV function. CRF (peak oxygen consumption), percent body fat (dual-energy x-ray absorptiometry), abdominal adipose tissue (MRI), and blood biochemistry markers were also evaluated. Results Adolescents with obesity showed significantly poorer LV function compared to normal-weight adolescents (P < 0.05) indicated by higher GLS (+ 6.29%) and SR in systole (+ 0.17 s− 1), and lower SR in early diastole (− 0.61 s− 1), and tissue Doppler velocities (S′ − 2.7 cm/s; e′ − 2.3 cm/s; A′ − 1.1 cm/s). There were no group differences in LV morphology when indexed to fat free mass (P > 0.05). Moderate to strong associations between myocardial contractility and relaxation, adiposity, arterial blood pressure and cardiorespiratory fitness were noted (r = 0.49–0.71, P < 0.05). Conclusion Obesity in adolescence is associated with altered LV systolic and diastolic function. The notable relationship between LV function, CRF and adiposity highlights the potential utility of multidisciplinary lifestyle interventions to treat diminished LV function in this population. Clinical trial registration: NCT01991106.
AB - Background Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature all-cause mortality. The aim of this study was to determine differences in LV morphology and function in obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory fitness (CRF) and adiposity were explored. Methods LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normal-weight [BMI equivalent to 18 kg/m2–25 kg/m2] and 9 obese [BMI equivalent to ≥ 30 kg/m2]); 13.3 ± 1.1 years, 45% female, Tanner puberty stage 3 [2–4]) using magnetic resonance imaging (MRI). Global longitudinal strain (GLS), strain rate (SR) and traditional echocardiographic indices were used to assess LV function. CRF (peak oxygen consumption), percent body fat (dual-energy x-ray absorptiometry), abdominal adipose tissue (MRI), and blood biochemistry markers were also evaluated. Results Adolescents with obesity showed significantly poorer LV function compared to normal-weight adolescents (P < 0.05) indicated by higher GLS (+ 6.29%) and SR in systole (+ 0.17 s− 1), and lower SR in early diastole (− 0.61 s− 1), and tissue Doppler velocities (S′ − 2.7 cm/s; e′ − 2.3 cm/s; A′ − 1.1 cm/s). There were no group differences in LV morphology when indexed to fat free mass (P > 0.05). Moderate to strong associations between myocardial contractility and relaxation, adiposity, arterial blood pressure and cardiorespiratory fitness were noted (r = 0.49–0.71, P < 0.05). Conclusion Obesity in adolescence is associated with altered LV systolic and diastolic function. The notable relationship between LV function, CRF and adiposity highlights the potential utility of multidisciplinary lifestyle interventions to treat diminished LV function in this population. Clinical trial registration: NCT01991106.
KW - Adiposity
KW - Cardiorespiratory fitness
KW - Global longitudinal strain
KW - Global longitudinal strain rate
KW - Left ventricular mass
KW - Tissue Doppler velocities
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U2 - 10.1016/j.ijcard.2017.03.047
DO - 10.1016/j.ijcard.2017.03.047
M3 - Article
C2 - 28372865
AN - SCOPUS:85016414030
SN - 0167-5273
VL - 240
SP - 313
EP - 319
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -