Legg-Calve-Perthes disease: Etiology, pathogenesis, and biology

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Legg-Calve-Perthes disease is a complex pediatric hip disorder with many uncertainties. Various theories on its etiology have been proposed but none have been validated conclusively. Through experimental studies, however, some insight into the pathogenesis of a femoral head deformity after ischemic necrosis has been gained. These studies reveal that mechanical and biological factors contribute to the development of the femoral head deformity. Better understanding of the pathobiology of Legg-Calve-Perthes disease will lead to the development of more effective treatments, which are able to specifically target the pathogenic processes.

Original languageEnglish (US)
Pages (from-to)S141-S146
JournalJournal of Pediatric Orthopaedics
Volume31
Issue numberSUPPL. 2
DOIs
StatePublished - Sep 1 2011

Keywords

  • Legg-Calve-Perthes disease
  • avascular necrosis
  • etiology
  • femoral head deformity
  • pathogenesis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine

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