Leprosy-associated renal disease: Case report and review of the literature

N. Ahsan, D. E. Wheeler, B. F. Palmer

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Leprosy is an infectious disease the principal clinical manifestations of which are anesthetic skin lesions and the development of peripheral neuropathy. The most common renal manifestation in leprosy patients is glomerulonephritis. Both immunofluorescent and electron microscopic studies suggest that the varied glomerular lesions found in these patients are immune complex mediated. Other renal lesions that have been described include amyloidosis, tubulointerstitial disease, acute renal failure, and functional defects in the absence of identifiable histologic abnormalities. In this report, a patient is described who developed the clinical syndrome of rapidly progressive glomerulonephritis. The renal biopsy showed a diffuse endocapillary proliferative process with electron-dense deposits in the glomerular subendothelial and subepithelial spaces. Organisms consistent with Mycobacterium leprae were identified within several of the glomeruli.

Original languageEnglish (US)
Pages (from-to)1546-1552
Number of pages7
JournalJournal of the American Society of Nephrology
Volume5
Issue number8
StatePublished - 1995

Keywords

  • acute renal failure
  • amyloidosis
  • glomerulonephritis
  • interstitial nephritis
  • leprosy

ASJC Scopus subject areas

  • Nephrology

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