Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area

Carol F. Elias, Carl Aschkenasi, Charlotte Lee, Joseph Kelly, Rexford S. Ahima, Christian Bjorbæk, Jeffrey S. Flier, Clifford B. Saper, Joel K. Elmquist

Research output: Contribution to journalArticle

676 Citations (Scopus)

Abstract

Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin- sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis.

Original languageEnglish (US)
Pages (from-to)775-786
Number of pages12
JournalNeuron
Volume23
Issue number4
DOIs
StatePublished - Aug 1999

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Lateral Hypothalamic Area
Pro-Opiomelanocortin
Neuropeptide Y
Leptin
Neurons
Messenger RNA
Body Weight
Cytokines
Arcuate Nucleus of Hypothalamus
Feeding Behavior
Homeostasis
Eating

ASJC Scopus subject areas

  • Neuroscience(all)

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Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. / Elias, Carol F.; Aschkenasi, Carl; Lee, Charlotte; Kelly, Joseph; Ahima, Rexford S.; Bjorbæk, Christian; Flier, Jeffrey S.; Saper, Clifford B.; Elmquist, Joel K.

In: Neuron, Vol. 23, No. 4, 08.1999, p. 775-786.

Research output: Contribution to journalArticle

Elias, CF, Aschkenasi, C, Lee, C, Kelly, J, Ahima, RS, Bjorbæk, C, Flier, JS, Saper, CB & Elmquist, JK 1999, 'Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area', Neuron, vol. 23, no. 4, pp. 775-786. https://doi.org/10.1016/S0896-6273(01)80035-0
Elias, Carol F. ; Aschkenasi, Carl ; Lee, Charlotte ; Kelly, Joseph ; Ahima, Rexford S. ; Bjorbæk, Christian ; Flier, Jeffrey S. ; Saper, Clifford B. ; Elmquist, Joel K. / Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. In: Neuron. 1999 ; Vol. 23, No. 4. pp. 775-786.
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