Lesion sites that predict the ability to gesture how an object is used

C. J. Price, J. T. Crinion, A. P. Leff, F. M. Richardson, T. M. Schofield, S. Prejawa, S. Ramsden, K. Gazarian, M. Lawrence, L. Ambridge, M. Andric, S. L. Small, M. L. Seghier

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We used a two stage procedure to predict which stroke patients would have chronic difficulties gesturing how to use an object when object recognition and hand movements were intact. First, we searched our PLORAS database by behavior and identified 5 patients who had chronic difficulty gesturing object use but no difficulty recognising objects, comprehending words or moving their hands. High definition lesion analyses showed that all 5 patients had damage to the white matter underlying the left ventral supramarginal gyrus, (A) close to the cortex, (B) deep towards the midline and (C) extending into the temporal lobe. In addition, 2 patients had damage to (D) the left posterior middle temporal cortex, and 3 patients had damage to (E) the left dorsal supramarginal gyrus and (F) the left premotor cortex. Second, we searched our database by lesion location for patients who had damage to any part of regions ABCDEF. The incidence of gesturing difficulties was higher in patients with damage to ABCD (7/9), ABCE (7/10) or ABCDE (10/13) than ABCF (7/13), ABC (8/16) or partial damage to ABCF (6/32). Thus behaviour was best predicted by the combination of regions that were damaged (a "network-lesion") rather than on the basis of each region alone or overall lesion size. Our results identify which parts of the temporal and parietal lobes impair the ability to gesture object use and which parts need to be intact to support it after damage. Our methods provide a framework for future studies aiming to predict the consequences of brain damage.

Original languageEnglish (US)
Pages (from-to)243-258
Number of pages16
JournalArchives Italiennes de Biologie
Volume148
Issue number3
StatePublished - Dec 28 2010
Externally publishedYes

Fingerprint

Gestures
Aptitude
Parietal Lobe
Temporal Lobe
Hand
Databases
Motor Cortex
Stroke
Incidence
Brain

Keywords

  • Aphasia
  • fMRI
  • Gesturing
  • Network lesions
  • PLORAS

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Price, C. J., Crinion, J. T., Leff, A. P., Richardson, F. M., Schofield, T. M., Prejawa, S., ... Seghier, M. L. (2010). Lesion sites that predict the ability to gesture how an object is used. Archives Italiennes de Biologie, 148(3), 243-258.

Lesion sites that predict the ability to gesture how an object is used. / Price, C. J.; Crinion, J. T.; Leff, A. P.; Richardson, F. M.; Schofield, T. M.; Prejawa, S.; Ramsden, S.; Gazarian, K.; Lawrence, M.; Ambridge, L.; Andric, M.; Small, S. L.; Seghier, M. L.

In: Archives Italiennes de Biologie, Vol. 148, No. 3, 28.12.2010, p. 243-258.

Research output: Contribution to journalArticle

Price, CJ, Crinion, JT, Leff, AP, Richardson, FM, Schofield, TM, Prejawa, S, Ramsden, S, Gazarian, K, Lawrence, M, Ambridge, L, Andric, M, Small, SL & Seghier, ML 2010, 'Lesion sites that predict the ability to gesture how an object is used', Archives Italiennes de Biologie, vol. 148, no. 3, pp. 243-258.
Price CJ, Crinion JT, Leff AP, Richardson FM, Schofield TM, Prejawa S et al. Lesion sites that predict the ability to gesture how an object is used. Archives Italiennes de Biologie. 2010 Dec 28;148(3):243-258.
Price, C. J. ; Crinion, J. T. ; Leff, A. P. ; Richardson, F. M. ; Schofield, T. M. ; Prejawa, S. ; Ramsden, S. ; Gazarian, K. ; Lawrence, M. ; Ambridge, L. ; Andric, M. ; Small, S. L. ; Seghier, M. L. / Lesion sites that predict the ability to gesture how an object is used. In: Archives Italiennes de Biologie. 2010 ; Vol. 148, No. 3. pp. 243-258.
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