Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation)

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10 Citations (Scopus)

Abstract

Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities.

Original languageEnglish (US)
JournalTransplant Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Ganciclovir
Cytomegalovirus
Foscarnet
Off-Label Use
Mutation
Cytomegalovirus Infections
United States Food and Drug Administration
Stem Cells
Genotype
Transplants
AIC246
Transplant Recipients
cidofovir

Keywords

  • Cytomegalovirus
  • Ganciclovir resistance
  • Heart transplant
  • Letermovir
  • UL97 mutation

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

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title = "Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation)",
abstract = "Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities.",
keywords = "Cytomegalovirus, Ganciclovir resistance, Heart transplant, Letermovir, UL97 mutation",
author = "Chong, {Pearlie P.} and Dagny Teiber and Prokesch, {Bonnie C.} and Arasaratnam, {Reuben J.} and Matthias Peltz and Drazner, {Mark H.} and Sonia Garg",
year = "2018",
month = "1",
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language = "English (US)",
journal = "Transplant Infectious Disease",
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T1 - Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation)

AU - Chong, Pearlie P.

AU - Teiber, Dagny

AU - Prokesch, Bonnie C.

AU - Arasaratnam, Reuben J.

AU - Peltz, Matthias

AU - Drazner, Mark H.

AU - Garg, Sonia

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities.

AB - Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities.

KW - Cytomegalovirus

KW - Ganciclovir resistance

KW - Heart transplant

KW - Letermovir

KW - UL97 mutation

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