Leukocyte beta-catenin expression is disturbed in systemic lupus erythematosus

Jacob J. Orme, Yong Du, Kamala Vanarsa, Tianfu Wu, Anne B. Satterthwaite, Chandra Mohan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Wnt/β-catenin signaling is relatively understudied in immunity and autoimmunity. β-catenin blocks inflammatory mediators and favors tolerogenic dendritic cell (DC) phenotypes. We show here that leukocytes from lupus-prone mice and SLE patients express diminished β-catenin transcriptional activity, particularly in myeloid cells, although other leukocytes revealed similar trends. Serum levels of DKK-1, an inhibitor under transcriptional control of Wnt/β-catenin, were also decreased in lupus-prone mice. Surprisingly, however, preemptive deletion of β-catenin from macrophages appears to have no effect on lupus development, even in mice with varying genetic loads for lupus. Although myeloid-specific loss of β-catenin does not seem to be important for lupus development, the potential role of this transcription factor in other leukocytes and renal cells remain to be elucidated.

Original languageEnglish (US)
Article numbere0161682
JournalPloS one
Volume11
Issue number8
DOIs
StatePublished - Aug 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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