Levels of Endothelial Nitric Oxide Synthase and Calcitonin Gene-related Peptide in the Charcot Foot: A Pilot Study

Javier La Fontaine, Lawrence B. Harkless, Victor L. Sylvia, David Carnes, Josefine Heim-Hall, Edward Jude

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The pathogenesis of Charcot neuroarthropathy is unclear. To investigate the possibility that decreased levels of calcitonin gene-related peptide and endothelial nitric oxide synthase are involved in the process, we studied bone samples from healthy subjects (n = 4), subjects with diabetic neuropathy (n = 4), and subjects with Charcot neuroarthropathy (n = 4). A statistically significant difference was found in endothelial nitric oxide synthase expression between bone specimens in patients with diabetic neuropathy, Charcot neuroarthropathy, and normal bone (P = .008). A trend toward calcitonin gene-related peptide intensification was observed in normal bone as compared to diabetic neuropathy and Charcot neuroarthropathy bone specimens, but it did not reached statistical significance (P = .23). This pilot study suggests that abnormal calcitonin gene-related peptide and endothelial nitric oxide synthase activity may play a role in the development of Charcot neuroarthropathy. Level of Clinical Evidence: 4.

Original languageEnglish (US)
Pages (from-to)424-429
Number of pages6
JournalJournal of Foot and Ankle Surgery
Volume47
Issue number5
DOIs
StatePublished - Sep 2008

Keywords

  • Charcot neuroarthropathy
  • calcitonin
  • diabetes
  • endothelial nitric oxide synthase
  • neuropathy

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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