Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study

Magnus Nakrem Lyngbakken, James A. de Lemos, Kristian Hveem, Helge Røsjø, Torbjørn Omland

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregulation affect these associations remain unclear. Methods: We analyzed cTnI with a high-sensitivity assay in 9739 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017–2019). BMI was assessed at study Visit 1 (1984–1986), 2 (1995–1997), 3 (2006–2008), and 4. Results: Median age at visit 4 was 68.7 years and 59% were women. Concentrations of cTnI were detectable in 84.1% of study participants, with a median of 2.5 (1.5–4.5 ng/L). We identified three clusters of BMI trajectories from visit 1 to 4, (1) stable normal weight, (2) stable overweight, and (3) stable obesity. Participants in clusters 2 and 3 were at increased risk of elevated concentrations of cTnI at visit 4 (odds ratio 1.27, 95% CI 1.09–1.47, and odds ratio 1.70, 95% CI 1.33–2.17, p for trend <0.001). Participants in cluster 3 had 22.0 (95% CI 14.1–29.9%) higher concentrations of cTnI compared to participants in cluster 1 (p for trend <0.001). Dysregulated glucose metabolism and abdominal obesity did not influence our results. Conclusions: Individuals with stable overweight or obesity are at increased risk of subclinical myocardial injury, independently of glycemic dysregulation and abdominal adiposity. Our data support a direct detrimental effect of long-standing obesity on cardiovascular health.

Original languageEnglish (US)
JournalJournal of Internal Medicine
DOIs
StateAccepted/In press - 2021

Keywords

  • cardiovascular risk factors
  • epidemiology
  • obesity
  • troponin

ASJC Scopus subject areas

  • Internal Medicine

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