Lifetime risk for heart failure among white and black americans

Cardiovascular lifetime risk pooling project

Mark D. Huffman, Jarett D. Berry, Hongyan Ning, Alan R. Dyer, Daniel B. Garside, Xuan Cai, Martha L. Daviglus, Donald M. Lloyd-Jones

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objectives: This study sought to estimate lifetime risk for heart failure (HF) by sex and race. Background: Prior estimates of lifetime risk for developing HF range from 20% to 33% in predominantly white cohorts. Short-term risks for HF appear higher for blacks than whites, but only limited comparisons of lifetime risk for HF have been made. Methods: Using public-release and internal datasets from National Heart, Lung, and Blood Institute-sponsored cohorts, we estimated lifetime risks for developing HF to age 95 years, with death free of HF as the competing event, among participants in the CHA (Chicago Heart Association Detection Project in Industry), ARIC (Atherosclerosis Risk in Communities), and CHS (Cardiovascular Health Study) cohorts. Results: There were 39,578 participants (33,652 [85%] white; 5,926 [15%] black) followed for 716,976 person-years; 5,983 participants developed HF. At age 45 years, lifetime risks for HF through age 95 years in CHA and CHS were 30% to 42% in white men, 20% to 29% in black men, 32% to 39% in white women, and 24% to 46% in black women. Results for ARIC demonstrated similar lifetime risks for HF in blacks and whites through age 75 years (limit of follow-up). Lifetime risk for HF was higher with higher blood pressure and body mass index at all ages in both blacks and whites, and did not diminish substantially with advancing index age. Conclusions: These are among the first data to compare lifetime risks for HF between blacks and whites. Lifetime risks for HF are high and appear similar for black and white women, yet are somewhat lower for black compared with white men due to competing risks.

Original languageEnglish (US)
Pages (from-to)1510-1517
Number of pages8
JournalJournal of the American College of Cardiology
Volume61
Issue number14
DOIs
StatePublished - Apr 9 2013

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Heart Failure
hydroquinone
Atherosclerosis
National Heart, Lung, and Blood Institute (U.S.)
Health
Industry
Body Mass Index
Cohort Studies
Hypertension

Keywords

  • epidemiology
  • heart failure
  • lifetime risk

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lifetime risk for heart failure among white and black americans : Cardiovascular lifetime risk pooling project. / Huffman, Mark D.; Berry, Jarett D.; Ning, Hongyan; Dyer, Alan R.; Garside, Daniel B.; Cai, Xuan; Daviglus, Martha L.; Lloyd-Jones, Donald M.

In: Journal of the American College of Cardiology, Vol. 61, No. 14, 09.04.2013, p. 1510-1517.

Research output: Contribution to journalArticle

Huffman, Mark D. ; Berry, Jarett D. ; Ning, Hongyan ; Dyer, Alan R. ; Garside, Daniel B. ; Cai, Xuan ; Daviglus, Martha L. ; Lloyd-Jones, Donald M. / Lifetime risk for heart failure among white and black americans : Cardiovascular lifetime risk pooling project. In: Journal of the American College of Cardiology. 2013 ; Vol. 61, No. 14. pp. 1510-1517.
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abstract = "Objectives: This study sought to estimate lifetime risk for heart failure (HF) by sex and race. Background: Prior estimates of lifetime risk for developing HF range from 20{\%} to 33{\%} in predominantly white cohorts. Short-term risks for HF appear higher for blacks than whites, but only limited comparisons of lifetime risk for HF have been made. Methods: Using public-release and internal datasets from National Heart, Lung, and Blood Institute-sponsored cohorts, we estimated lifetime risks for developing HF to age 95 years, with death free of HF as the competing event, among participants in the CHA (Chicago Heart Association Detection Project in Industry), ARIC (Atherosclerosis Risk in Communities), and CHS (Cardiovascular Health Study) cohorts. Results: There were 39,578 participants (33,652 [85{\%}] white; 5,926 [15{\%}] black) followed for 716,976 person-years; 5,983 participants developed HF. At age 45 years, lifetime risks for HF through age 95 years in CHA and CHS were 30{\%} to 42{\%} in white men, 20{\%} to 29{\%} in black men, 32{\%} to 39{\%} in white women, and 24{\%} to 46{\%} in black women. Results for ARIC demonstrated similar lifetime risks for HF in blacks and whites through age 75 years (limit of follow-up). Lifetime risk for HF was higher with higher blood pressure and body mass index at all ages in both blacks and whites, and did not diminish substantially with advancing index age. Conclusions: These are among the first data to compare lifetime risks for HF between blacks and whites. Lifetime risks for HF are high and appear similar for black and white women, yet are somewhat lower for black compared with white men due to competing risks.",
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AU - Berry, Jarett D.

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AU - Dyer, Alan R.

AU - Garside, Daniel B.

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AU - Daviglus, Martha L.

AU - Lloyd-Jones, Donald M.

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AB - Objectives: This study sought to estimate lifetime risk for heart failure (HF) by sex and race. Background: Prior estimates of lifetime risk for developing HF range from 20% to 33% in predominantly white cohorts. Short-term risks for HF appear higher for blacks than whites, but only limited comparisons of lifetime risk for HF have been made. Methods: Using public-release and internal datasets from National Heart, Lung, and Blood Institute-sponsored cohorts, we estimated lifetime risks for developing HF to age 95 years, with death free of HF as the competing event, among participants in the CHA (Chicago Heart Association Detection Project in Industry), ARIC (Atherosclerosis Risk in Communities), and CHS (Cardiovascular Health Study) cohorts. Results: There were 39,578 participants (33,652 [85%] white; 5,926 [15%] black) followed for 716,976 person-years; 5,983 participants developed HF. At age 45 years, lifetime risks for HF through age 95 years in CHA and CHS were 30% to 42% in white men, 20% to 29% in black men, 32% to 39% in white women, and 24% to 46% in black women. Results for ARIC demonstrated similar lifetime risks for HF in blacks and whites through age 75 years (limit of follow-up). Lifetime risk for HF was higher with higher blood pressure and body mass index at all ages in both blacks and whites, and did not diminish substantially with advancing index age. Conclusions: These are among the first data to compare lifetime risks for HF between blacks and whites. Lifetime risks for HF are high and appear similar for black and white women, yet are somewhat lower for black compared with white men due to competing risks.

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