Ligand-conjugated quantum dots for targeted drug delivery to nerve cells

Tania Q. Vu, Ravikanth Maddipati, Todd A. Blute, Barrett J. Nehilla, Leora Nusblat, Tejal A. Desai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased interest in nanoparticle quantum dots as fluorescent probes possessing extended photostability, multi-color capability, and surface-controllable properties has made apparent their promising potential for biological and therapeutic applications. As an approach towards surface-functionalized nanoparticle drug delivery, here we report the development of quantum dots (QDs) complexed with the small peptide hormone ßNGF. Surface modification and composition of ligand-conjugated QDs were confirmed using atomic force microscopy. Bioactivity and visual localization of ligand-QD complexes was assayed in live cells. Despite known structural and chemical stringency of ligand-receptor activation, we provide evidence to support activation of cell-surface trkA membrane receptor channels and downstream modulation of neurite sprouting. This QD-based capability bears significance for development of surface-conjugated nanoparticle drug delivery.

Original languageEnglish (US)
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages152-153
Number of pages2
DOIs
StatePublished - Dec 1 2005
Externally publishedYes
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Conference

Conference2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period5/12/055/15/05

Keywords

  • AFM
  • Drug delivery
  • Ligand
  • Nanobiotechnology
  • Nanostructures
  • Neuron
  • Quantum dots
  • Receptor
  • Stimulation

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Vu, T. Q., Maddipati, R., Blute, T. A., Nehilla, B. J., Nusblat, L., & Desai, T. A. (2005). Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 152-153). [1548410] (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548410