Ligand-coupled lipoprotein for ovarian cancer-specific drug delivery

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Lipoproteins are natural nanosized delivery vehicles within the circulatory system of all mammals. Scientists have long been interested in utilizing these endogenous macromolecules to transport exogenous imaging or therapeutic agents to specific cells or tissues in the body. The broad distribution of lipoprotein receptors throughout the body however has limited the utility of this approach for targeted delivery of medicinal agents. In recent years lipoprotein rerouting strategies have been developed wherein lipoproteins can be redirected from their natural lipoprotein receptors to an alternate receptor of choice. In this chapter we describe the basic methods of preparing folic acid-conjugated high-density lipoprotein nanoparticles for targeted delivery of imaging or chemotherapeutic agents to ovarian cancer cells.

Original languageEnglish (US)
Title of host publicationOvarian Cancer
Subtitle of host publicationMethods and Protocols
EditorsAnastasia Malek, Oleg Tchernitsa
Pages467-480
Number of pages14
DOIs
StatePublished - Aug 21 2013

Publication series

NameMethods in Molecular Biology
Volume1049
ISSN (Print)1064-3745

Keywords

  • Folate receptor
  • Folic acid
  • High-density lipoprotein
  • Nanoparticles

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Corbin, I. R. (2013). Ligand-coupled lipoprotein for ovarian cancer-specific drug delivery. In A. Malek, & O. Tchernitsa (Eds.), Ovarian Cancer: Methods and Protocols (pp. 467-480). (Methods in Molecular Biology; Vol. 1049). https://doi.org/10.1007/978-1-62703-547-7_35