The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.
- DRD1-Gs complex
- allosteric regulation
- dopamine receptor
- positive allosteric modulator
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)