Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Behzad Aghazadeh; Michael K. Rosen

doi:10.1016/S1074-5521(99)80108-2

Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Behzad Aghazadeh, Michael K. Rosen

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting thee interactions.

Original language	English (US)
Pages (from-to)	R241-R246
Journal	Chemistry and Biology
Volume	6
Issue number	9
DOIs	https://doi.org/10.1016/S1074-5521(99)80108-2
State	Published - Sep 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(99)80108-2

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title = "Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices",

abstract = "SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting thee interactions.",

author = "Behzad Aghazadeh and Rosen, {Michael K.}",

year = "1999",

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AB - SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting thee interactions.

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Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Abstract

ASJC Scopus subject areas

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