Ligand recognition by SH3 and WW domains

The role of N-alkylation in PPII helices

Behzad Aghazadeh, Michael K. Rosen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting thee interactions.

Original languageEnglish (US)
JournalChemistry and Biology
Volume6
Issue number9
DOIs
StatePublished - 1999

Fingerprint

src Homology Domains
Alkylation
Ligands
Proline
polyproline

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Ligand recognition by SH3 and WW domains : The role of N-alkylation in PPII helices. / Aghazadeh, Behzad; Rosen, Michael K.

In: Chemistry and Biology, Vol. 6, No. 9, 1999.

Research output: Contribution to journalArticle

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