Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Behzad Aghazadeh, Michael K. Rosen

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting thee interactions.

Original languageEnglish (US)
Pages (from-to)R241-R246
JournalChemistry and Biology
Volume6
Issue number9
DOIs
StatePublished - Sep 1999

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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