Light chain deposition disease in an older adult patient successfully treated with long-term administration of bortezomib, melphalan and prednisone

Hiroto Hiyamuta, Shunsuke Yamada, Yuta Matsukuma, Akihiro Tsuchimoto, Toshiaki Nakano, Masatomo Taniguchi, Kosuke Masutani, Goichi Yoshimoto, Tsuyoshi Muta, Koichi Akashi, Takanari Kitazono, Kazuhiko Tsuruya

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Abstract

A 70-year-old woman was admitted to our hospital because of fatigue and renal dysfunction and was diagnosed with light chain deposition disease (LCDD) with multiple organ involvement (kidney, thyroid gland, heart and eyes). After chemotherapy with bortezomib, cyclophosphamide and dexamethasone, hepatobiliary enzyme levels increased abruptly. A liver biopsy showed light chain deposition in Disse spaces. After two years of treatment with bortezomib, melphalan and prednisone (VMP) administered at shorter intervals relative to regular cycles, the patient showed a hematological and organ response. This case indicates that a relatively low dose intensity VMP regimen is preferable for elderly patients with LCDD with multiple organ involvement.

Original languageEnglish (US)
Pages (from-to)1319-1325
Number of pages7
JournalInternal Medicine
Volume55
Issue number10
DOIs
StatePublished - 2016

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Keywords

  • Cardiac involvement
  • Liver involvement
  • Multiple myeloma
  • Ocular involvement
  • VMP therapy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hiyamuta, H., Yamada, S., Matsukuma, Y., Tsuchimoto, A., Nakano, T., Taniguchi, M., Masutani, K., Yoshimoto, G., Muta, T., Akashi, K., Kitazono, T., & Tsuruya, K. (2016). Light chain deposition disease in an older adult patient successfully treated with long-term administration of bortezomib, melphalan and prednisone. Internal Medicine, 55(10), 1319-1325. https://doi.org/10.2169/internalmedicine.55.5752