TY - JOUR
T1 - Light-induced degradation of TIMELESS and entrainment of the drosophila circadian clock
AU - Myers, Michael P.
AU - Wager-Smith, Karen
AU - Rothenfluh-Hilfiker, Adrian
AU - Young, Michael W.
PY - 1996/3/22
Y1 - 1996/3/22
N2 - Two genes, period (per) and timeless (tim), are required for production of circadian rhythms in Drosophila. The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. Tim accumulated rhythmically in nuclei of eyes and pacemaker cells of the brain. The phase of these rhythms was differently advanced or delayed by light pulses delivered at different times of the day, corresponding with phase shifts induced in the behavioral rhythms.
AB - Two genes, period (per) and timeless (tim), are required for production of circadian rhythms in Drosophila. The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. Tim accumulated rhythmically in nuclei of eyes and pacemaker cells of the brain. The phase of these rhythms was differently advanced or delayed by light pulses delivered at different times of the day, corresponding with phase shifts induced in the behavioral rhythms.
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U2 - 10.1126/science.271.5256.1736
DO - 10.1126/science.271.5256.1736
M3 - Article
C2 - 8596937
AN - SCOPUS:0029989521
SN - 0036-8075
VL - 271
SP - 1736
EP - 1740
JO - Science
JF - Science
IS - 5256
ER -