Light-induced metal-free transformations of unactivated pyridotriazoles

Ziyan Zhang, Dongari Yadagiri, Vladimir Gevorgyan

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9 Scopus citations

Abstract

A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X-H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules.

Original languageEnglish (US)
Pages (from-to)8399-8404
Number of pages6
JournalChemical Science
Volume10
Issue number36
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)

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